{"id":"W2974509005","doi":"10.1186/s12872-019-1187-z","title":"Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9","year":2019,"lang":"en","type":"article","venue":"BMC Cardiovascular Disorders","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Population Health Research Institute","funders":"National Institute of Mental Health; National Heart, Lung, and Blood Institute; Netherlands Heart Institute; Det Sundhedsvidenskabelige Fakultet, Københavns Universitet; Medical Research Council; Economic and Social Research Council; Berlin Institute of Health; Hjartavernd; Faculty of Health and Medical Sciences, University of Western Australia; Rheinische Friedrich-Wilhelms-Universität Bonn; Centre hospitalier régional universitaire de Lille; Freie Universität Berlin; Deutsche Krebshilfe; Deutsche Forschungsgemeinschaft; Universität Potsdam; Northwest Regional Development Agency; Engineering and Physical Sciences Research Council; Humboldt-Universität zu Berlin; Institut National de la Santé et de la Recherche Médicale; Blood Cancer UK; Erasmus Medisch Centrum; University of Oxford; Wellcome Trust; Cancer Research UK; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; British Heart Foundation; Versus Arthritis; Agence Nationale de la Recherche; Novo Nordisk; Bundesministerium für Bildung und Forschung; National Institute on Aging; National Institute for Health and Care Research; National Institutes of Health; Rosetrees Trust; Université de Lille; Alan Turing Institute; South Australian Health and Medical Research Institute; Novo Nordisk Foundation Center for Basic Metabolic Research; Universität zu Lübeck; John D. and Catherine T. MacArthur Foundation; National Institute for Social Care and Health Research","keywords":"PCSK9; Medicine; Internal medicine; Angiology; Odds ratio; Single-nucleotide polymorphism; Mendelian randomization; Diabetes mellitus; Type 2 diabetes; Myocardial infarction; Placebo; Cholesterol; Endocrinology; Genotype; Lipoprotein; Genetics; Pathology; LDL receptor; Genetic variants; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001786142,0.0002471265,0.001518962,0.0006677083,0.00003478279,0.00002149871,0.0001506109,0.0002065549,0.0000953702],"category_scores_gemma":[0.0002828184,0.0002498649,0.003143763,0.001662894,0.00002464408,0.0001037563,0.00006762367,0.0002375917,0.00004800474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000364802,"about_ca_system_score_gemma":0.0001707254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001853326,"about_ca_topic_score_gemma":0.0008595771,"domain_scores_codex":[0.9968505,0.0002474044,0.0005957561,0.0005891586,0.001236384,0.0004808143],"domain_scores_gemma":[0.9980152,0.0001046049,0.0001698447,0.001456896,0.000120293,0.0001331646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00004925176,0.0001179078,0.9307326,0.0003411296,0.01250014,0.000006808955,0.0001989557,0.03903009,0.00007135193,0.000005059591,0.0000102287,0.01693645],"study_design_scores_gemma":[0.003487969,0.00007652691,0.9855852,0.00008131379,0.005329328,0.00000363144,0.0002129885,0.001856376,0.00006179247,0.00002096456,0.003048747,0.0002351384],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790385,0.006521531,0.01077516,0.00006357281,0.0002246134,0.001185238,0.00001253447,0.00004375805,0.002135102],"genre_scores_gemma":[0.9981064,0.0007838118,0.0006206904,0.0001359674,0.00007225719,0.00005917524,0.00004869257,0.00004709463,0.0001259032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0548526,"threshold_uncertainty_score":0.9999954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007738540087034135,"score_gpt":0.2227026085511974,"score_spread":0.2149640684641633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}