{"id":"W2974509005","doi":"10.1186/s12872-019-1187-z","title":"Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9","year":2019,"lang":"en","type":"article","venue":"BMC Cardiovascular Disorders","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Population Health Research Institute","funders":"National Institute of Mental Health; National Heart, Lung, and Blood Institute; Netherlands Heart Institute; Det Sundhedsvidenskabelige Fakultet, Københavns Universitet; Medical Research Council; Economic and Social Research Council; Berlin Institute of Health; Hjartavernd; Faculty of Health and Medical Sciences, University of Western Australia; Rheinische Friedrich-Wilhelms-Universität Bonn; Centre hospitalier régional universitaire de Lille; Freie Universität Berlin; Deutsche Krebshilfe; Deutsche Forschungsgemeinschaft; Universität Potsdam; Northwest Regional Development Agency; Engineering and Physical Sciences Research Council; Humboldt-Universität zu Berlin; Institut National de la Santé et de la Recherche Médicale; Blood Cancer UK; Erasmus Medisch Centrum; University of Oxford; Wellcome Trust; Cancer Research UK; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; British Heart Foundation; Versus Arthritis; Agence Nationale de la Recherche; Novo Nordisk; Bundesministerium für Bildung und Forschung; National Institute on Aging; National Institute for Health and Care Research; National Institutes of Health; Rosetrees Trust; Université de Lille; Alan Turing Institute; South Australian Health and Medical Research Institute; Novo Nordisk Foundation Center for Basic Metabolic Research; Universität zu Lübeck; John D. and Catherine T. MacArthur Foundation; National Institute for Social Care and Health Research","keywords":"PCSK9; Medicine; Internal medicine; Angiology; Odds ratio; Single-nucleotide polymorphism; Mendelian randomization; Diabetes mellitus; Type 2 diabetes; Myocardial infarction; Placebo; Cholesterol; Endocrinology; Genotype; Lipoprotein; Genetics; Pathology; LDL receptor; Genetic variants; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001918113,0.0003952868,0.0005010248,0.0008221212,0.0002670603,0.0004637557,0.0003868063,0.0005390165,0.002153839],"category_scores_gemma":[0.003354148,0.0001722408,0.001035525,0.001558457,0.0002995806,0.0001479379,0.0004173953,0.0004509722,0.0001727369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001857329,"about_ca_system_score_gemma":0.000233201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002077566,"about_ca_topic_score_gemma":0.001995035,"domain_scores_codex":[0.9985298,0.0006459784,0.000127663,0.0004777207,0.0001362149,0.00008276712],"domain_scores_gemma":[0.9969102,0.001470317,0.0008654331,0.0003408976,0.0002142782,0.0001989414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006222558,0.0000925606,0.9641787,0.0002214541,0.005451907,0.0005206497,0.0001060461,0.001277065,0.01158861,0.0002070586,0.0003450509,0.009788333],"study_design_scores_gemma":[0.0002239683,0.0004428094,0.9948359,0.00001267122,0.001748911,0.0004158944,0.00003842462,0.0009015912,0.0007621823,0.0001563971,0.0004512782,0.00001011716],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997404,0.0006650047,0.0008087142,0.00005397519,0.00001016981,0.00001599822,0.000799084,0.00001057761,0.0002323959],"genre_scores_gemma":[0.9986003,0.0001356985,0.0005952622,0.00002250825,0.00001270583,0.00001733005,0.0004962829,0.000005176844,0.0001147505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002153839,"threshold_uncertainty_score":0.01014405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007738540087034135,"score_gpt":0.2227026085511974,"score_spread":0.2149640684641633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}