{"id":"W2974513151","doi":"10.1016/j.jcjd.2019.07.014","title":"7 - TXNIP Promotes GAPDH Nuclear Translocation by High Glucose","year":2019,"lang":"en","type":"article","venue":"Canadian Journal of Diabetes","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"TXNIP; Thioredoxin-Interacting Protein; Glyceraldehyde 3-phosphate dehydrogenase; Endocrinology; Downregulation and upregulation; Thioredoxin; Diabetic nephropathy; Internal medicine; Medicine; Oxidative stress; Biology; Molecular biology; Diabetes mellitus; Biochemistry; Enzyme; Dehydrogenase","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002817046,0.0007235011,0.0005271314,0.0003559364,0.0005395606,0.0007477796,0.0005678543,0.0003992289,0.004454669],"category_scores_gemma":[0.0002319846,0.0004202221,0.0006291578,0.0004879045,0.0009103735,0.0004769867,0.000537038,0.001707246,0.0009063131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001325368,"about_ca_system_score_gemma":0.001240622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0122937,"about_ca_topic_score_gemma":0.0157381,"domain_scores_codex":[0.9996874,0.00004143969,0.00002037188,0.00005567144,0.00005244042,0.0001426228],"domain_scores_gemma":[0.9997379,0.00005564723,0.00003147477,0.00004310362,0.00003216842,0.00009967713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006261293,0.0003351446,0.0003275484,0.0001201769,0.00002091406,0.0002884331,0.0001511922,0.0001542307,0.9889271,0.0005411826,0.0005382762,0.002334472],"study_design_scores_gemma":[0.0001314201,0.0007256097,0.005881521,0.00001951904,0.00002485069,0.0001696163,0.0002664748,0.0007376337,0.9897454,0.0001581417,0.002125654,0.000014093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982137,0.003515177,0.003479483,0.001190293,0.0006230114,0.00008347936,0.001081872,0.0003427416,0.007546963],"genre_scores_gemma":[0.9869196,0.0009229448,0.001378859,0.0001504601,0.00006917776,0.00006300029,0.001141309,0.00006441008,0.009290234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0122937,"threshold_uncertainty_score":0.02444428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003477397839979206,"score_gpt":0.1877094621484206,"score_spread":0.1842320643084414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}