{"id":"W2974525672","doi":"10.1681/asn.2019030218","title":"Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen","year":2019,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Chronic Kidney Disease and Diabetes","field":"Medicine","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Hospital for Sick Children; McMaster University; University of Toronto; Institute of Population and Public Health","funders":"National Institute of Mental Health; Medical Research Council; National Institutes of Health; Servier; National Eye Institute; Academy of Finland; Samfundet Folkhälsan; Novo Nordisk Fonden; Public Health Agency; Novo Nordisk; National Institute for Health and Care Research; Steno Diabetes Center Copenhagen; Wellcome Trust; European Foundation for the Study of Diabetes; Science Foundation Ireland; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Folkhälsanin Tutkimussäätiö; Vetenskapsrådet; Astellas Pharma; Lietuvos Sveikatos Mokslų Universitetas; Wilhelm och Else Stockmanns Stiftelse; National Heart, Lung, and Blood Institute; Helsingin ja Uudenmaan Sairaanhoitopiiri; University of Dundee; National Institute of Diabetes and Digestive and Kidney Diseases; Wellcome; Sanofi; Pfizer","keywords":"Glomerular basement membrane; Basement membrane; Kidney disease; Disease; Medicine; Genome-wide association study; Internal medicine; Kidney; Biology; Pathology; Endocrinology; Genetics; Glomerulonephritis; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002263802,0.0005162543,0.0007408049,0.001586587,0.0004585176,0.001306935,0.0005237582,0.0006930507,0.001734067],"category_scores_gemma":[0.004280427,0.0002533626,0.001709508,0.003399642,0.0004676012,0.0003863447,0.0005709964,0.001179108,0.0001367204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000347065,"about_ca_system_score_gemma":0.0004882253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004620174,"about_ca_topic_score_gemma":0.006576547,"domain_scores_codex":[0.9984478,0.0006143173,0.0001501435,0.0004048671,0.0002795415,0.0001033584],"domain_scores_gemma":[0.9967197,0.001739271,0.0007448082,0.0003015314,0.0002625312,0.000232172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001243172,0.00005695725,0.9278703,0.0008811777,0.01744058,0.0004923379,0.0001521729,0.0009796706,0.008493185,0.0008628709,0.003254603,0.03827291],"study_design_scores_gemma":[0.0001186314,0.0001197255,0.9801957,0.0002076382,0.008523147,0.0006590202,0.0001300501,0.001375741,0.001337807,0.002621254,0.004683743,0.00002750834],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8172203,0.1565559,0.008694238,0.007024953,0.0008759645,0.00004571093,0.005219797,0.0001652185,0.004197884],"genre_scores_gemma":[0.9802371,0.01469074,0.002340737,0.0007575323,0.0004268216,0.00002011132,0.001130166,0.00002234017,0.0003745303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004620174,"threshold_uncertainty_score":0.01197225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009078117604329666,"score_gpt":0.2523115459468867,"score_spread":0.243233428342557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}