{"id":"W2974525672","doi":"10.1681/asn.2019030218","title":"Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen","year":2019,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Chronic Kidney Disease and Diabetes","field":"Medicine","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Hospital for Sick Children; McMaster University; University of Toronto; Institute of Population and Public Health","funders":"National Institute of Mental Health; Medical Research Council; National Institutes of Health; Servier; National Eye Institute; Academy of Finland; Samfundet Folkhälsan; Novo Nordisk Fonden; Public Health Agency; Novo Nordisk; National Institute for Health and Care Research; Steno Diabetes Center Copenhagen; Wellcome Trust; European Foundation for the Study of Diabetes; Science Foundation Ireland; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Folkhälsanin Tutkimussäätiö; Vetenskapsrådet; Astellas Pharma; Lietuvos Sveikatos Mokslų Universitetas; Wilhelm och Else Stockmanns Stiftelse; National Heart, Lung, and Blood Institute; Helsingin ja Uudenmaan Sairaanhoitopiiri; University of Dundee; National Institute of Diabetes and Digestive and Kidney Diseases; Wellcome; Sanofi; Pfizer","keywords":"Glomerular basement membrane; Basement membrane; Kidney disease; Disease; Medicine; Genome-wide association study; Internal medicine; Kidney; Biology; Pathology; Endocrinology; Genetics; Glomerulonephritis; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000663465,0.0001615834,0.001016499,0.0001127322,0.00003149027,0.000003495639,0.0002784145,0.00006972447,0.000153967],"category_scores_gemma":[0.0004032236,0.0001128541,0.0004978601,0.0004769354,0.0002335656,0.00005222344,0.0001117265,0.0001860671,0.000004453058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004094142,"about_ca_system_score_gemma":0.0007801459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001589359,"about_ca_topic_score_gemma":0.00001079399,"domain_scores_codex":[0.9979246,0.000390368,0.0007884933,0.0001852375,0.0004026552,0.0003086335],"domain_scores_gemma":[0.9968733,0.0004547819,0.001746444,0.0003814886,0.0002558084,0.0002881326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005535466,0.001310981,0.8681403,0.0001379187,0.0009441347,0.000005170943,0.0007273458,0.00005897772,0.1221701,0.000004991097,0.005910234,0.00003629521],"study_design_scores_gemma":[0.005863116,0.002229615,0.9817913,0.00007629737,0.0007024759,9.80206e-7,0.001767254,0.000107252,0.001218257,0.0001285741,0.006013758,0.0001011516],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850382,0.0005115629,0.000003639722,0.01370367,0.0001306178,0.0005503774,0.00002687036,0.000004911639,0.00003016517],"genre_scores_gemma":[0.9880285,0.0003643348,0.0001272051,0.01125495,0.0001130035,0.000006781259,0.000009762763,0.00001568322,0.00007981619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1209519,"threshold_uncertainty_score":0.4602056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009078117604329666,"score_gpt":0.2523115459468867,"score_spread":0.243233428342557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}