{"id":"W2974579064","doi":"10.1016/j.eururo.2019.08.034","title":"Androgen Receptor Modulation Optimized for Response—Splice Variant: A Phase 3, Randomized Trial of Galeterone Versus Enzalutamide in Androgen Receptor Splice Variant-7–expressing Metastatic Castration-resistant Prostate Cancer","year":2019,"lang":"en","type":"article","venue":"European Urology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"National Cancer Institute","keywords":"Enzalutamide; Prostate cancer; Medicine; Androgen receptor; Androgen deprivation therapy; Internal medicine; Oncology; Clinical endpoint; Circulating tumor cell; Androgen; Docetaxel; Urology; Randomized controlled trial; Cancer research; Cancer; Metastasis; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008614632,0.001297685,0.001962909,0.000331785,0.0002863489,0.001045095,0.0007450319,0.0009766114,0.004625635],"category_scores_gemma":[0.000772938,0.0004298218,0.001691104,0.0003296542,0.00107188,0.0008363636,0.0002731443,0.003214733,0.0005581851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007723015,"about_ca_system_score_gemma":0.0006886593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001360602,"about_ca_topic_score_gemma":0.004104026,"domain_scores_codex":[0.9996836,0.0001555669,0.00001417569,0.00005522693,0.00002049957,0.00007097732],"domain_scores_gemma":[0.9996439,0.00008876088,0.00006818519,0.0000291291,0.00001718661,0.0001529162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.964563,0.004289424,0.001062275,0.0003312273,0.001535205,0.00005644087,0.0000536043,0.0008904759,0.004486564,0.0002538238,0.001346233,0.02113185],"study_design_scores_gemma":[0.9012057,0.08992831,0.004458914,0.0000399601,0.0009315778,0.00008076235,0.00005470708,0.001265387,0.0006266604,0.0004136093,0.0009621176,0.00003235814],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931898,0.002672671,0.0003468851,0.0006753211,0.0004020972,0.0004913085,0.00045006,0.0001145887,0.001657309],"genre_scores_gemma":[0.9943542,0.001056428,0.0005939063,0.0009251519,0.0002245379,0.0003573915,0.0006289002,0.0000273784,0.001832147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004625635,"threshold_uncertainty_score":0.01547432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04215919260931933,"score_gpt":0.3414474701722842,"score_spread":0.2992882775629649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}