{"id":"W2974579064","doi":"10.1016/j.eururo.2019.08.034","title":"Androgen Receptor Modulation Optimized for Response—Splice Variant: A Phase 3, Randomized Trial of Galeterone Versus Enzalutamide in Androgen Receptor Splice Variant-7–expressing Metastatic Castration-resistant Prostate Cancer","year":2019,"lang":"en","type":"article","venue":"European Urology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"National Cancer Institute","keywords":"Enzalutamide; Prostate cancer; Medicine; Androgen receptor; Androgen deprivation therapy; Internal medicine; Oncology; Clinical endpoint; Circulating tumor cell; Androgen; Docetaxel; Urology; Randomized controlled trial; Cancer research; Cancer; Metastasis; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003430256,0.0003462963,0.001225449,0.0003711557,0.0001004621,0.00002764595,0.0001821717,0.0001037041,0.0004273354],"category_scores_gemma":[0.0009067261,0.0002846009,0.0002432126,0.000336381,0.0002069987,0.0001891473,0.00006935179,0.0002754871,0.00004558717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002009687,"about_ca_system_score_gemma":0.000465227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001241649,"about_ca_topic_score_gemma":0.00001819841,"domain_scores_codex":[0.9947075,0.002567639,0.001063074,0.0007070014,0.0003663081,0.0005884265],"domain_scores_gemma":[0.9968082,0.001740412,0.0005182299,0.0004929658,0.0002581293,0.0001820258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7759287,0.0005080666,0.00001754581,0.000130064,0.0005157098,0.0001064745,0.001371556,0.0006893867,0.2188639,0.00002580051,0.0001474741,0.001695296],"study_design_scores_gemma":[0.9716051,0.00586003,0.00006466854,0.0001322073,0.0005641953,0.00002511885,0.0001392936,0.008070175,0.009915848,0.00002562425,0.003326315,0.000271475],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871427,0.001471473,0.0007708204,0.001279917,0.0006803672,0.007648085,0.0003854386,0.00005556023,0.0005656473],"genre_scores_gemma":[0.9899524,0.0006152641,0.00661085,0.000120943,0.0002360546,0.0006858883,0.0005147879,0.0001175663,0.001146191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2089481,"threshold_uncertainty_score":0.9999606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04215919260931933,"score_gpt":0.3414474701722842,"score_spread":0.2992882775629649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}