{"id":"W2974645484","doi":"10.1111/jth.14639","title":"Randomized phase 2 trial comparing JNJ‐9375, a thrombin‐directed antibody, with apixaban for prevention of venous thrombosis","year":2019,"lang":"en","type":"article","venue":"Journal of Thrombosis and Haemostasis","topic":"Venous Thromboembolism Diagnosis and Management","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"Johnson and Johnson","keywords":"Apixaban; Venous thrombosis; Thrombin generation; Randomized controlled trial; Medicine; Antibody; Venous thromboembolism; Thrombosis; Thrombin; Internal medicine; Cardiology; Pharmacology; Atrial fibrillation; Warfarin; Rivaroxaban; Immunology; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001866685,0.002498128,0.004808854,0.0005710484,0.0005819599,0.002062664,0.00122031,0.002163503,0.01319376],"category_scores_gemma":[0.002805422,0.001105277,0.002545814,0.000569302,0.001239615,0.001437998,0.0005134492,0.004828846,0.001882457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001084924,"about_ca_system_score_gemma":0.001691807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002675573,"about_ca_topic_score_gemma":0.005537572,"domain_scores_codex":[0.9992071,0.0003868682,0.00005209151,0.0001770558,0.00006669789,0.0001103011],"domain_scores_gemma":[0.9989674,0.0003671257,0.0002078905,0.00008979809,0.0000713895,0.0002964551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9864079,0.002167239,0.0002028139,0.0006221946,0.001658559,0.00004021838,0.00002636927,0.0001876316,0.0009230149,0.0001757748,0.001058792,0.006529415],"study_design_scores_gemma":[0.9914969,0.007148072,0.0003445004,0.0000210792,0.0004157319,0.00001572848,0.000008496721,0.0001086042,0.00005434741,0.00006848014,0.000311244,0.000006847886],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9427676,0.01902786,0.002749301,0.0041245,0.00518418,0.009759159,0.005844505,0.0005518355,0.009991211],"genre_scores_gemma":[0.9514832,0.009215149,0.005148461,0.005525347,0.001972744,0.009079768,0.004431765,0.0001217971,0.01302176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01319376,"threshold_uncertainty_score":0.04413754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07045307229754515,"score_gpt":0.3837513293849941,"score_spread":0.3132982570874489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}