{"id":"W2974722301","doi":"10.1016/j.dental.2019.08.104","title":"Alternative model for cathepsin K activation in human dentin","year":2019,"lang":"en","type":"article","venue":"Dental Materials","topic":"Dental Erosion and Treatment","field":"Dentistry","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Dentin; N-terminal telopeptide; Materials science; Cathepsin K; Ultimate tensile strength; Type I collagen; Demineralization; Cathepsin; Nuclear chemistry; Molar; Chromatography; Dentistry; Chemistry; Biochemistry; Composite material; Alkaline phosphatase; Osteocalcin; Enzyme; Medicine; Enamel paint; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001266598,0.0001381664,0.0002091632,0.00008776171,0.00004538613,0.0001037282,0.0001339475,0.0000660435,0.0008421236],"category_scores_gemma":[0.000009478983,0.0001299855,0.00005939035,0.0000483122,0.00001502558,0.0001950483,0.00006959109,0.00003175793,0.0009273853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001599673,"about_ca_system_score_gemma":0.000008693169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004104378,"about_ca_topic_score_gemma":0.0001754198,"domain_scores_codex":[0.9990548,0.00003526652,0.0002830407,0.0002630032,0.0001720773,0.0001918509],"domain_scores_gemma":[0.9996338,0.00002172492,0.0001171536,0.0001705608,0.0000203226,0.00003638325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001255077,0.0002386286,0.008538734,0.00003585148,0.00001745365,0.000008737394,0.0001825773,0.00009851786,0.986114,0.004404109,0.0001588316,0.00007706245],"study_design_scores_gemma":[0.002560796,0.00005791575,0.02389056,0.00006321914,0.00001103156,0.000009384312,0.000119019,0.001155634,0.9691064,0.002823175,0.00003761298,0.0001652901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970098,0.000003703457,0.0004431099,0.000009327228,0.0009105309,0.0007620294,0.0001287414,0.00003652616,0.0006962156],"genre_scores_gemma":[0.9931276,8.573635e-7,0.000162354,0.00008096464,0.00005033976,0.0001373046,0.0002531833,0.00002759797,0.006159808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01700762,"threshold_uncertainty_score":0.9998505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03135644052619282,"score_gpt":0.3206374795276924,"score_spread":0.2892810390014996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}