{"id":"W2974736094","doi":"10.1523/jneurosci.0730-19.2019","title":"Depletion of Caveolin-1 in Type 2 Diabetes Model Induces Alzheimer's Disease Pathology Precursors","year":2019,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Caveolin-1 and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; National Institute of Allergy and Infectious Diseases; U.S. Department of Veterans Affairs","keywords":"Hyperphosphorylation; Downregulation and upregulation; Amyloid precursor protein; Caveolin 1; Endocrinology; Internal medicine; Presenilin; Alzheimer's disease; Cell biology; Wild type; Small hairpin RNA; Diabetes mellitus; Biology; Chemistry; Disease; Medicine; Mutant; Kinase; Apoptosis; Biochemistry; Gene knockdown; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001533802,0.0003870064,0.0003748633,0.0003031352,0.0002443155,0.0003853629,0.0002366547,0.0004881342,0.00185955],"category_scores_gemma":[0.00008710905,0.0002237831,0.0003711811,0.0002236956,0.000213025,0.0002410666,0.0002331561,0.001099238,0.0004361182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000277026,"about_ca_system_score_gemma":0.0002570508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006448019,"about_ca_topic_score_gemma":0.0007321017,"domain_scores_codex":[0.9998376,0.00001629111,0.00001811904,0.00004586648,0.00003515461,0.00004687109],"domain_scores_gemma":[0.9998941,0.000008640071,0.00002575445,0.00001277659,0.000008627153,0.00005008572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005707282,0.0002522701,0.0003946903,0.00005873574,0.00001555142,0.0002456809,0.0000320106,0.0000474431,0.9968882,0.0001354566,0.0001495269,0.001209644],"study_design_scores_gemma":[0.0003366615,0.003466962,0.01729152,0.00003667003,0.0001050531,0.00238511,0.0001230706,0.002249263,0.9639639,0.0002453351,0.00977267,0.00002377609],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932413,0.001469409,0.002140499,0.0002164301,0.000157159,0.00008291237,0.0006272932,0.0001433703,0.001921658],"genre_scores_gemma":[0.9883915,0.001857513,0.0022025,0.00023693,0.00004349197,0.0002390914,0.001051871,0.00005531592,0.005921907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00185955,"threshold_uncertainty_score":0.006220818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01750755541928153,"score_gpt":0.2577209574989062,"score_spread":0.2402134020796246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}