{"id":"W2974739675","doi":"10.1021/acs.jmedchem.9b00294","title":"Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and <i>Trypanosoma cruzi</i> Cruzain","year":2019,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Fogarty International Center; National Institutes of Health","keywords":"Trypanosoma cruzi; Cysteine protease; Chagas disease; Chemistry; Proteases; Amastigote; Cathepsin; Cathepsin L; Biochemistry; Cathepsin B; Cysteine Proteinase Inhibitors; Cysteine; Protease; Intracellular; Cathepsin D; Enzyme; Biology; Virology; Leishmania; Programmed cell death; Parasite hosting","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001399837,0.0003160152,0.0002832407,0.000190775,0.0001016324,0.0002759082,0.0003727791,0.0002136232,0.0009606837],"category_scores_gemma":[0.0001268473,0.0001433715,0.0001967548,0.0001737335,0.0001452555,0.0002101971,0.0001786586,0.0003693049,0.0002163533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002934749,"about_ca_system_score_gemma":0.0002333614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005982541,"about_ca_topic_score_gemma":0.001518384,"domain_scores_codex":[0.9999337,0.00001412412,0.000007830919,0.00001434479,0.00001337723,0.00001654511],"domain_scores_gemma":[0.9999549,0.000005309127,0.00001474537,0.000004263156,0.000007642234,0.00001311853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000565537,0.0002556366,0.0002671171,0.0001909522,0.00003288679,0.0002122409,0.00004958872,0.001843412,0.9846202,0.000648159,0.0002004186,0.01111378],"study_design_scores_gemma":[0.0005817398,0.008404544,0.002840173,0.0000324042,0.000139995,0.0005850189,0.00006092358,0.004369845,0.9671137,0.000252147,0.01558265,0.00003691398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866297,0.004304656,0.004138292,0.0001425238,0.00003928027,0.0003116229,0.0003539774,0.0000826963,0.003997201],"genre_scores_gemma":[0.991397,0.002280223,0.004124384,0.00009933226,0.00001004779,0.00006344213,0.0003829728,0.000008591037,0.001633982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009606837,"threshold_uncertainty_score":0.003213763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01361365136470277,"score_gpt":0.2783086177937028,"score_spread":0.264694966429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}