{"id":"W2974739675","doi":"10.1021/acs.jmedchem.9b00294","title":"Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and <i>Trypanosoma cruzi</i> Cruzain","year":2019,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Fogarty International Center; National Institutes of Health","keywords":"Trypanosoma cruzi; Cysteine protease; Chagas disease; Chemistry; Proteases; Amastigote; Cathepsin; Cathepsin L; Biochemistry; Cathepsin B; Cysteine Proteinase Inhibitors; Cysteine; Protease; Intracellular; Cathepsin D; Enzyme; Biology; Virology; Leishmania; Programmed cell death; Parasite hosting","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000107507,0.0001602118,0.0005414184,0.00008727473,0.00005751736,0.000008321986,0.0002744677,0.0001140006,0.0001386661],"category_scores_gemma":[0.0006816841,0.00009848656,0.0001774687,0.000258797,0.0003873401,0.00006650532,0.00007937533,0.0005141406,0.000001911097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009140098,"about_ca_system_score_gemma":0.0005672242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004928502,"about_ca_topic_score_gemma":8.66012e-7,"domain_scores_codex":[0.9977787,0.00007278485,0.0007984462,0.0001565352,0.000965722,0.0002278576],"domain_scores_gemma":[0.9978857,0.0001536914,0.0007552049,0.0003917881,0.0005387149,0.0002749019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004095295,0.0002676733,0.004750913,0.0006439021,0.0001121095,0.00004130139,0.0001737692,0.00001267959,0.9919478,0.00002091742,0.001132496,0.0004869582],"study_design_scores_gemma":[0.003024964,0.002005361,0.08898474,0.001962258,0.0001943599,0.002468916,0.0008646682,0.00003540251,0.8992283,0.0002919975,0.0008325987,0.0001064021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940318,0.001565804,0.0001177288,0.00233477,0.0000498937,0.0004534626,0.000009055755,0.00000512729,0.001432367],"genre_scores_gemma":[0.9980623,0.0001626166,0.000360169,0.0001056254,0.0002503016,0.000005835066,0.000002718685,0.00001659071,0.001033861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09271942,"threshold_uncertainty_score":0.4016165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01361365136470277,"score_gpt":0.2783086177937028,"score_spread":0.264694966429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}