{"id":"W2974771668","doi":"10.1016/j.chembiol.2019.09.004","title":"Discovery and Development of TMPRSS6 Inhibitors Modulating Hepcidin Levels in Human Hepatocytes","year":2019,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; GlaxoSmithKline","keywords":"Hepcidin; TMPRSS6; Homeostasis; Serine protease; Ferroportin; Transmembrane protein; Cell biology; Chemistry; Biology; Biochemistry; Protease; Receptor; Immunology; Enzyme; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002267299,0.0004143884,0.0003666673,0.0002746843,0.0001471018,0.0003939046,0.0002611096,0.0002296085,0.001597562],"category_scores_gemma":[0.0001128909,0.0001702264,0.0003283986,0.0001509625,0.0001169528,0.0001417371,0.0001559412,0.0007208834,0.0003818952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000310111,"about_ca_system_score_gemma":0.0002872115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000518401,"about_ca_topic_score_gemma":0.001665246,"domain_scores_codex":[0.9999424,0.000008842247,0.000004088175,0.000009889067,0.00001521841,0.00001956876],"domain_scores_gemma":[0.9999658,0.00000580842,0.000007922848,0.000003158812,0.000008386298,0.000009086405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001238176,0.0003686768,0.000597581,0.0002386725,0.00007660606,0.0002842593,0.00003813902,0.001250252,0.9556465,0.0007800088,0.001328621,0.0381526],"study_design_scores_gemma":[0.0007090452,0.003762282,0.002663032,0.00002975395,0.0001775452,0.000918414,0.00004564453,0.003986021,0.9640657,0.0001859015,0.02343836,0.00001811194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9492387,0.02478788,0.01237012,0.001135769,0.0003011856,0.0004299883,0.001258633,0.0003647645,0.01011292],"genre_scores_gemma":[0.9770254,0.0110432,0.004918407,0.000279175,0.00005555233,0.0001218614,0.001300086,0.00002464107,0.005231782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001597562,"threshold_uncertainty_score":0.005344331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01884197464511083,"score_gpt":0.2627920763691745,"score_spread":0.2439501017240637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}