{"id":"W2974885357","doi":"10.1093/jncics/pkz071","title":"Survival in Early Phase Immuno-Oncology Trials: Development and Validation of a Prognostic Index","year":2019,"lang":"en","type":"article","venue":"JNCI Cancer Spectrum","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"American Society of Clinical Oncology","keywords":"Medicine; Hazard ratio; Internal medicine; Confidence interval; Multivariate analysis; Oncology; Cohort; Clinical trial; Proportional hazards model; Progression-free survival; Overall survival","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03206234,0.0005344236,0.001002939,0.00134558,0.0003131883,0.001547565,0.0006961209,0.0005218277,0.0008578189],"category_scores_gemma":[0.0416449,0.0001495625,0.0003992308,0.001331877,0.000509981,0.00130319,0.001077193,0.001005456,0.000312017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007477315,"about_ca_system_score_gemma":0.001006073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002607512,"about_ca_topic_score_gemma":0.0002906478,"domain_scores_codex":[0.9900649,0.006928836,0.0011544,0.0005352892,0.0009986301,0.0003179952],"domain_scores_gemma":[0.9369143,0.03382638,0.01815057,0.002138671,0.005815452,0.003154644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004816155,0.0001281807,0.9362661,0.000154681,0.0001753845,0.00003555362,0.00008320177,0.001568052,0.00105881,0.0002609885,0.002101167,0.05335173],"study_design_scores_gemma":[0.00133476,0.009478092,0.9331959,0.0002851611,0.0006854379,0.0008564094,0.0002064506,0.03761286,0.00616341,0.001943793,0.008173633,0.00006408031],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753176,0.006097627,0.01159217,0.001184847,0.0001361672,0.0005405875,0.001717065,0.0001081922,0.003305833],"genre_scores_gemma":[0.9934796,0.0004161255,0.003922019,0.000216832,0.0001231256,0.0003333981,0.001361208,0.00001174908,0.0001358353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03206234,"threshold_uncertainty_score":0.1695639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04345991597609218,"score_gpt":0.3606200229043465,"score_spread":0.3171601069282544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}