{"id":"W2974885357","doi":"10.1093/jncics/pkz071","title":"Survival in Early Phase Immuno-Oncology Trials: Development and Validation of a Prognostic Index","year":2019,"lang":"en","type":"article","venue":"JNCI Cancer Spectrum","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"American Society of Clinical Oncology","keywords":"Medicine; Hazard ratio; Internal medicine; Confidence interval; Multivariate analysis; Oncology; Cohort; Clinical trial; Proportional hazards model; Progression-free survival; Overall survival","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009714611,0.0001266751,0.0005757193,0.0001764403,0.00001906709,0.00001079165,0.0000584938,0.0001016266,0.0003897363],"category_scores_gemma":[0.00006547078,0.0001056695,0.00006210756,0.0002571975,0.0000517219,0.00006907056,0.00002370201,0.0001221044,0.000005673545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003811477,"about_ca_system_score_gemma":0.0007113034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00120805,"about_ca_topic_score_gemma":0.0004431469,"domain_scores_codex":[0.9986777,0.000106655,0.0005741625,0.0002201574,0.0002106292,0.0002106998],"domain_scores_gemma":[0.9993758,0.0001468133,0.0002415111,0.0001548683,0.000035347,0.00004571642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01508093,0.0005447764,0.7991985,0.0002337353,0.0003934515,0.00002160049,0.003570554,0.000004533944,0.05886773,0.00008272111,0.00008655239,0.1219149],"study_design_scores_gemma":[0.02845377,0.001972257,0.792906,0.0004193161,0.0000939434,0.00001931086,0.000432559,0.00007823727,0.159054,0.00008870942,0.01623504,0.0002468436],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949805,0.001877997,0.00004769859,0.0007427926,0.0006058608,0.0008987343,0.000008128125,0.00001686669,0.0008214906],"genre_scores_gemma":[0.9989597,0.0003573227,0.0001125409,0.00008648606,0.00009658895,0.0000822978,0.00001146349,0.00001498148,0.0002785877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.121668,"threshold_uncertainty_score":0.4309078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04345991597609218,"score_gpt":0.3606200229043465,"score_spread":0.3171601069282544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}