{"id":"W2974888135","doi":"10.1158/2159-8290.cd-19-0154","title":"Infiltrating Myeloid Cells Drive Osteosarcoma Progression via GRM4 Regulation of IL23","year":2019,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital","funders":"Cancer Council NSW; National Health and Medical Research Council","keywords":"Osteosarcoma; Myeloid cells; Interleukin 23; Cancer research; Myeloid; Biology; Immunology; Inflammation; Interleukin 17","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003818446,0.0003616575,0.0002641071,0.0002149503,0.0002019578,0.0004987075,0.0005143191,0.001078716,0.002071069],"category_scores_gemma":[0.0003695708,0.0001619222,0.000196232,0.0001151461,0.0008626329,0.0003067185,0.0006283997,0.002719389,0.0008685755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006955267,"about_ca_system_score_gemma":0.0005091611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005558618,"about_ca_topic_score_gemma":0.001257875,"domain_scores_codex":[0.9997367,0.00004927504,0.00001240476,0.00004572769,0.0001134488,0.00004242301],"domain_scores_gemma":[0.9997874,0.00005385347,0.0000571431,0.00001421187,0.00004809963,0.00003935813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001191032,0.0001367394,0.001053301,0.0006521039,0.0000380905,0.001071756,0.0001163162,0.0004066475,0.7526329,0.01350958,0.1728123,0.05637922],"study_design_scores_gemma":[0.0003985068,0.0009684949,0.00937618,0.0002637634,0.00009148295,0.00126605,0.0002330116,0.001657507,0.3400328,0.008915785,0.6367415,0.00005497776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.2782908,0.2706855,0.03524552,0.3025884,0.06177645,0.0004139908,0.002573369,0.002891411,0.04553461],"genre_scores_gemma":[0.663555,0.1472325,0.006347059,0.05743171,0.02536544,0.0003834101,0.0007959739,0.000297299,0.09859161],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002071069,"threshold_uncertainty_score":0.006928444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008548975603706675,"score_gpt":0.2437075837683834,"score_spread":0.2351586081646767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}