{"id":"W2974971672","doi":"10.1038/s41467-019-12298-z","title":"High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":182,"is_retracted":false,"has_abstract":true,"ca_institutions":"Decipher Biosciences (Canada); McGill University Health Centre","funders":"DOD Prostate Cancer Research Program; Cancer Research Society; Cancer Prevention and Research Institute of Texas; Alexander and Margaret Stewart Trust; Dana-Farber Cancer Institute; National Cancer Institute; National Institutes of Health; Prostate Cancer Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; U.S. Department of Defense","keywords":"Prostate cancer; Prostate; Cancer research; Metabolome; Cancer; Tumor progression; Internal medicine; Biology; Histone; Endocrinology; Medicine; Gene; Genetics; Metabolite","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008153838,0.0002135306,0.000197649,0.0003022786,0.0001299524,0.0003979,0.0001242654,0.000187668,0.001668519],"category_scores_gemma":[0.00006783155,0.0001353584,0.0001990677,0.0002086627,0.0002469302,0.0001896995,0.0002522829,0.0004491991,0.000211472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002424027,"about_ca_system_score_gemma":0.0002504517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006429548,"about_ca_topic_score_gemma":0.001988502,"domain_scores_codex":[0.9999378,0.00001088751,0.000002443874,0.00001579782,0.00001656595,0.00001644698],"domain_scores_gemma":[0.9999086,0.00000700684,0.00002996143,0.00001116648,0.00001113444,0.00003230529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003626288,0.00003092441,0.002368977,0.00005434565,0.00002247645,0.00005468551,0.00001091564,0.0001024263,0.9934069,0.0002011032,0.00006296137,0.003321611],"study_design_scores_gemma":[0.00004140932,0.001152642,0.1081957,0.00003952364,0.0001003091,0.0009285187,0.00014052,0.001781881,0.878733,0.0009913275,0.007872168,0.00002290863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886164,0.003295252,0.005253307,0.0003880922,0.00003892601,0.00001407438,0.000567515,0.0001471391,0.001679262],"genre_scores_gemma":[0.995232,0.001667226,0.001417558,0.00006819812,0.00001325816,0.000006589668,0.0002013213,0.0000149702,0.00137886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001668519,"threshold_uncertainty_score":0.005581737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0105880154494768,"score_gpt":0.3162803953427926,"score_spread":0.3056923798933158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}