{"id":"W2974971672","doi":"10.1038/s41467-019-12298-z","title":"High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":182,"is_retracted":false,"has_abstract":true,"ca_institutions":"Decipher Biosciences (Canada); McGill University Health Centre","funders":"DOD Prostate Cancer Research Program; Cancer Research Society; Cancer Prevention and Research Institute of Texas; Alexander and Margaret Stewart Trust; Dana-Farber Cancer Institute; National Cancer Institute; National Institutes of Health; Prostate Cancer Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; U.S. Department of Defense","keywords":"Prostate cancer; Prostate; Cancer research; Metabolome; Cancer; Tumor progression; Internal medicine; Biology; Histone; Endocrinology; Medicine; Gene; Genetics; Metabolite","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002685365,0.0001456033,0.0001400908,0.00001794883,0.0004332399,0.00008742384,0.0007771107,0.0001934121,0.000009118941],"category_scores_gemma":[0.00005444465,0.00008296834,0.00006009522,0.0001507645,0.0002183325,0.00001023643,0.0005602438,0.0005743407,0.000004181424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001249126,"about_ca_system_score_gemma":0.00005116572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006796443,"about_ca_topic_score_gemma":0.000288694,"domain_scores_codex":[0.9990885,0.0001482754,0.0001619723,0.0002481759,0.0001334419,0.0002196251],"domain_scores_gemma":[0.998137,0.00005263041,0.0001211785,0.001528502,0.000113948,0.00004671646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002469414,0.0002687616,0.01590914,0.00008000615,0.0003340276,3.005537e-8,0.001152489,0.0000220573,0.6014942,0.005303221,0.2146319,0.1605572],"study_design_scores_gemma":[0.0003022793,0.000060878,0.005675774,0.00002615975,0.00004901619,0.000002197418,0.0001403121,0.0000228665,0.005335089,0.0000693038,0.9881901,0.0001260398],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5384789,0.4383861,0.00001781874,0.01607651,0.003366753,0.002373066,0.0001668591,0.00007283139,0.001061144],"genre_scores_gemma":[0.9676653,0.0269955,0.001196294,0.000848715,0.001162672,0.0007115259,0.0002210482,0.0000263205,0.001172687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7735581,"threshold_uncertainty_score":0.3383351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0105880154494768,"score_gpt":0.3162803953427926,"score_spread":0.3056923798933158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}