{"id":"W2974979812","doi":"10.1200/jco.18.02057","title":"Developing a Highly Specific Biomarker for Germ Cell Malignancies: Plasma miR371 Expression Across the Germ Cell Malignancy Spectrum","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Testicular diseases and treatments","field":"Medicine","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of British Columbia","funders":"National Cancer Institute","keywords":"Medicine; Malignancy; Germ cell tumors; False positive paradox; Biomarker; Germ cell; Internal medicine; Blinding; Oncology; Predictive value of tests; Testicular Germ Cell Tumor; Predictive value; Gastroenterology; Pathology; Seminoma; Chemotherapy; Clinical trial; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001831829,0.0002710852,0.001324469,0.00007282795,0.0001309606,0.00003715615,0.0003125925,0.000394755,0.0001697955],"category_scores_gemma":[0.0006910786,0.0001501595,0.001005994,0.0001525232,0.0001558444,0.0001163026,0.0001164426,0.0004885477,0.0001567138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002554822,"about_ca_system_score_gemma":0.001631887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006542568,"about_ca_topic_score_gemma":0.000005598371,"domain_scores_codex":[0.996233,0.000277074,0.002132757,0.0003659569,0.0004487936,0.0005423602],"domain_scores_gemma":[0.9931859,0.003225761,0.002448387,0.0004209905,0.000321468,0.0003975324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02936753,0.01397475,0.744135,0.001456501,0.001593466,0.006321431,0.00109558,0.00004356126,0.03787437,0.000870795,0.03940713,0.1238599],"study_design_scores_gemma":[0.02814569,0.009297302,0.6115631,0.0008492867,0.0006511897,0.0006181989,0.0005442997,0.0001469568,0.01603112,0.0009571379,0.3308279,0.000367873],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987564,0.002687823,0.0005462755,0.004723812,0.002482708,0.000809752,0.00002657216,0.00001817763,0.001140908],"genre_scores_gemma":[0.9871704,0.0008484295,0.008269502,0.001222998,0.0008351071,0.00001852051,0.000009009575,0.0000439248,0.00158212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2914208,"threshold_uncertainty_score":0.6123328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.104573489272468,"score_gpt":0.4291364789550863,"score_spread":0.3245629896826184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}