{"id":"W2974980805","doi":"10.1016/bs.apcsb.2019.08.001","title":"Protein misfolding in endoplasmic reticulum stress with applications to renal diseases","year":2019,"lang":"en","type":"review","venue":"Advances in protein chemistry and structural biology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Joseph’s Healthcare Hamilton; McMaster University","funders":"","keywords":"Endoplasmic reticulum; Protein folding; Unfolded protein response; Protein aggregation; Proteostasis; Chemistry; Protein structure; Protein tertiary structure; Cell biology; Computational biology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0000622254,0.0005830117,0.0009878862,0.00006753101,0.00006686345,0.00003313882,0.0004095184,0.0004304434,0.00002375862],"category_scores_gemma":[0.00009363424,0.000440417,0.0001330334,0.0002486474,0.0002420251,0.00001524597,0.0002347544,0.0003591449,0.000003236004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004545375,"about_ca_system_score_gemma":0.0001901463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001433622,"about_ca_topic_score_gemma":0.00004210816,"domain_scores_codex":[0.9975196,0.0001101855,0.0005658774,0.001167881,0.0001089831,0.0005275475],"domain_scores_gemma":[0.998889,0.0000387926,0.000274566,0.0005528173,0.00004212448,0.0002026773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005784156,0.0001315622,0.003809348,0.03943179,0.0001763353,0.00009600641,0.00002866721,0.0002066574,0.03569829,0.0007996117,0.00001125388,0.919032],"study_design_scores_gemma":[0.002100431,0.0005455625,0.00008414095,0.01478988,0.0002591998,0.0001909808,0.0001008148,0.00002683909,0.05108032,0.0009889209,0.9275714,0.002261525],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05585815,0.9405098,0.00006066158,0.00002136635,0.00003557158,0.002572148,0.0005889257,0.00001548981,0.0003378934],"genre_scores_gemma":[0.07230015,0.9208766,0.001121412,0.00002260669,0.0002358262,0.003507721,0.001563768,0.00005814163,0.0003137368],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9275602,"threshold_uncertainty_score":0.9998047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008476707309104124,"score_gpt":0.3006633276338133,"score_spread":0.2921866203247092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}