{"id":"W2975010038","doi":"10.1016/j.stem.2019.09.003","title":"Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation","year":2019,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; European Research Council; Medical Research Council; Lundbeckfonden; Association Européenne contre les Leucodystrophies; National Institutes of Health; New York Stem Cell Foundation; Action Medical Research; Biotechnology and Biological Sciences Research Council; NIHR Cambridge Biomedical Research Centre; Rosetrees Trust; Cerebral Palsy Alliance Research Foundation; Novo Nordisk Fonden; National Multiple Sclerosis Society","keywords":"Unfolded protein response; Biology; Oligodendrocyte; Myelin; Leukodystrophy; Deferiprone; Proteolipid protein 1; Cell biology; Programmed cell death; Endoplasmic reticulum; Apoptosis; Cancer research; Myelin basic protein; Genetics; Biochemistry; Neuroscience; Pathology; Disease; Medicine; Deferoxamine; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001852934,0.0006482546,0.000528031,0.0008951626,0.0004085495,0.0003746761,0.0003148639,0.0008893539,0.002379945],"category_scores_gemma":[0.0003108751,0.0002158774,0.0003075281,0.0002869238,0.0005867089,0.0002869624,0.0005631375,0.0006433115,0.00049735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002000924,"about_ca_system_score_gemma":0.0002223572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007471737,"about_ca_topic_score_gemma":0.001030501,"domain_scores_codex":[0.9998177,0.00002608513,0.0000356294,0.00004270768,0.00004651206,0.00003148938],"domain_scores_gemma":[0.9998125,0.00002018416,0.00006704949,0.00002413282,0.00001601716,0.00006011602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000457244,0.00005890672,0.0006911782,0.0000612845,0.00002589703,0.002348781,0.00007646425,0.00008198857,0.9921821,0.0003258882,0.000156373,0.003533945],"study_design_scores_gemma":[0.0002706402,0.0006218729,0.02092085,0.00004392512,0.0001302689,0.0148244,0.0003039126,0.002066075,0.9489773,0.001106755,0.01069333,0.00004069649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942262,0.0006937053,0.00264314,0.0002096341,0.00007606118,0.00003030154,0.0003930658,0.0002377813,0.001490205],"genre_scores_gemma":[0.9937376,0.0004418294,0.002563811,0.00006882315,0.0000184778,0.00003870701,0.0002947561,0.00006152299,0.002774367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002379945,"threshold_uncertainty_score":0.00796175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00875123647093724,"score_gpt":0.2251831648076624,"score_spread":0.2164319283367252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}