{"id":"W2975037912","doi":"10.3390/microorganisms7100406","title":"Opinion: Are Organoids the End of Model Evolution for Studying Host Intestinal Epithelium/Microbe Interactions?","year":2019,"lang":"en","type":"review","venue":"Microorganisms","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; W. Garfield Weston Foundation","keywords":"Organoid; Intestinal epithelium; Cell biology; Biology; Epithelium; Ex vivo; Stem cell; Mucus; Secretion; Intestinal mucosa; Cellular differentiation; In vivo; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003900828,0.0004810886,0.001777179,0.000219595,0.00014876,0.00003784548,0.0003425086,0.0001929558,0.0002233184],"category_scores_gemma":[0.0001107743,0.0003222153,0.0007245408,0.0003948391,0.0001384597,0.00006914898,0.0001959428,0.0005566397,0.00009753001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005618741,"about_ca_system_score_gemma":0.0009746763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004416476,"about_ca_topic_score_gemma":0.00002216374,"domain_scores_codex":[0.9979674,0.00008034093,0.0008488505,0.0005354198,0.0002216887,0.0003463496],"domain_scores_gemma":[0.997715,0.0002533791,0.0008301205,0.0007651835,0.0003489719,0.00008736501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002538462,0.0009390621,0.00007780283,0.1054977,0.001963675,0.00001287068,0.001117682,0.00002486275,0.06597184,0.0005793832,0.02316337,0.8003979],"study_design_scores_gemma":[0.0008915425,0.0002503766,0.00001775406,0.01721489,0.003437246,0.0006172495,0.0003994661,0.00004256282,0.003771734,0.0000341549,0.9729328,0.0003901825],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008416593,0.9790415,0.01603234,0.0002750011,0.001235049,0.002608722,0.0005420116,0.00004436612,0.0001367992],"genre_scores_gemma":[0.0008200797,0.9904153,0.0050486,0.0001599952,0.0006404331,0.0001522646,0.0002832614,0.0001735127,0.002306507],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9497695,"threshold_uncertainty_score":0.999923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1221400673645595,"score_gpt":0.3696219834195266,"score_spread":0.2474819160549671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}