{"id":"W2975037912","doi":"10.3390/microorganisms7100406","title":"Opinion: Are Organoids the End of Model Evolution for Studying Host Intestinal Epithelium/Microbe Interactions?","year":2019,"lang":"en","type":"review","venue":"Microorganisms","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; W. Garfield Weston Foundation","keywords":"Organoid; Intestinal epithelium; Cell biology; Biology; Epithelium; Ex vivo; Stem cell; Mucus; Secretion; Intestinal mucosa; Cellular differentiation; In vivo; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.002108545,0.0005305861,0.001023617,0.0007778424,0.0002738104,0.001733502,0.001383025,0.002754142,0.004323208],"category_scores_gemma":[0.002321514,0.0002065581,0.0004939811,0.0009091807,0.001621953,0.003889373,0.0007325732,0.004263934,0.003509693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007847706,"about_ca_system_score_gemma":0.001332178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007208243,"about_ca_topic_score_gemma":0.001038398,"domain_scores_codex":[0.9995434,0.0001171148,0.00005173538,0.0000726046,0.0001826838,0.00003245085],"domain_scores_gemma":[0.9984364,0.000771012,0.0001317586,0.00005654182,0.0004948147,0.0001094769],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000122149,0.00004408732,0.0002143294,0.01632718,0.0000849542,0.0003981944,0.0001489435,0.0004478992,0.005719073,0.03457287,0.1856898,0.7562307],"study_design_scores_gemma":[0.000007264589,0.00003656795,0.0001375765,0.001554737,0.00003221234,0.0004809084,0.00008787593,0.00004680721,0.0004191706,0.005814962,0.9913684,0.00001351227],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.000225596,0.9717951,0.001200233,0.01857474,0.005495286,0.000008661909,0.00008034105,0.00002962445,0.002590394],"genre_scores_gemma":[0.00161326,0.9869638,0.0008898944,0.006150548,0.002240524,0.0000174305,0.0001001187,0.00001083468,0.002013659],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.9978914,"threshold_uncertainty_score":0.01446259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1221400673645595,"score_gpt":0.3696219834195266,"score_spread":0.2474819160549671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}