{"id":"W2975061401","doi":"10.1371/journal.pone.0222946","title":"Gene expression profiling of skeletal myogenesis in human embryonic stem cells reveals a potential cascade of transcription factors regulating stages of myogenesis, including quiescent/activated satellite cell-like gene expression","year":2019,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; Ontario Institute for Regenerative Medicine; Canada Research Chairs; University of Ottawa; Stem Cell Network; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Natural Sciences and Engineering Research Council of Canada; Muscular Dystrophy Association","keywords":"Myogenesis; Biology; Embryonic stem cell; Cell biology; Gene expression; Gene expression profiling; Transcription factor; Regulation of gene expression; Gene; Stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008619967,0.000182145,0.0001820331,0.0003708233,0.0001159986,0.0002200041,0.00005720117,0.000146432,0.0008524318],"category_scores_gemma":[0.00005974977,0.000131642,0.000205533,0.0004121236,0.0001207448,0.00009959526,0.0001038189,0.000178892,0.0004082237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001352852,"about_ca_system_score_gemma":0.0001670649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005764689,"about_ca_topic_score_gemma":0.001533217,"domain_scores_codex":[0.9999179,0.000006082424,0.000007020657,0.00002537328,0.00003078946,0.00001282904],"domain_scores_gemma":[0.9999619,0.000009639359,0.00001084928,0.000003205488,0.000007950732,0.000006509416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003209612,0.000004979716,0.0009608491,0.00002041189,0.000003385033,0.00002179604,0.00002117889,0.00003642052,0.9973797,0.00002191092,0.00001998868,0.001477391],"study_design_scores_gemma":[0.000004639333,0.0002420962,0.1277874,0.0000151135,0.00003178962,0.0002212661,0.00008822099,0.0008646256,0.8680831,0.00005412239,0.002600619,0.000007009233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905279,0.001524457,0.003706119,0.00003302081,0.000009169409,0.00002793661,0.002203614,0.00006079078,0.001907047],"genre_scores_gemma":[0.9650853,0.002877782,0.01340089,0.0001276398,0.00001465872,0.0001388986,0.009358744,0.0000576294,0.008938454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008524318,"threshold_uncertainty_score":0.002851665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02486744845418856,"score_gpt":0.2376481176333674,"score_spread":0.2127806691791788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}