{"id":"W2975077252","doi":"10.1210/en.2019-00504","title":"Protein Arginine Methyltransferase 1 Interacts With PGC1α and Modulates Thermogenic Fat Activation","year":2019,"lang":"en","type":"article","venue":"Endocrinology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Ministry of Science and ICT, South Korea; National Institute on Alcohol Abuse and Alcoholism; National Research Foundation; China Scholarship Council; American Heart Association; American Diabetes Association","keywords":"Biology; Thermogenesis; Endocrinology; Internal medicine; Adipose tissue; Methyltransferase; Adipocyte; White adipose tissue; Arginine; Brown adipose tissue; Thermogenin; Mitochondrial biogenesis; Cell biology; Function (biology); Methylation; Genetics; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002927064,0.0001410638,0.000133362,0.00005856629,0.00003064822,0.00001058737,0.00007087478,0.00009883445,0.00007010813],"category_scores_gemma":[0.00001222372,0.000120794,0.00002981221,0.00006519328,0.00005707625,0.000008345231,0.00003859023,0.000104974,0.00001717039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001741854,"about_ca_system_score_gemma":0.00002775127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003192834,"about_ca_topic_score_gemma":0.00002957119,"domain_scores_codex":[0.9991953,0.00005293456,0.0001233032,0.0003378735,0.00006480789,0.0002257668],"domain_scores_gemma":[0.9996054,0.00001145117,0.00005248648,0.0002461004,0.00004598797,0.00003853848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002951964,0.0000202313,0.001249412,0.00001332648,0.0000882773,0.000001644756,0.00004726256,0.0003632226,0.9883779,0.0001872004,0.00003410101,0.009322262],"study_design_scores_gemma":[0.001109675,0.0005539785,0.00690383,0.0000198807,0.00001506348,0.00005518357,0.00003109827,0.0002110474,0.9866271,0.00008783727,0.004224525,0.000160775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969777,0.0003876502,0.001169454,0.0004639711,0.00007674545,0.0004430435,0.00000405486,0.0000214392,0.0004558747],"genre_scores_gemma":[0.9983491,0.00006516507,0.0003377732,0.00007812638,0.0001061144,0.00004394995,0.00008947528,0.00002448278,0.00090576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009161487,"threshold_uncertainty_score":0.4925838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005107435525098753,"score_gpt":0.2184188283077874,"score_spread":0.2133113927826886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}