{"id":"W2975077252","doi":"10.1210/en.2019-00504","title":"Protein Arginine Methyltransferase 1 Interacts With PGC1α and Modulates Thermogenic Fat Activation","year":2019,"lang":"en","type":"article","venue":"Endocrinology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Ministry of Science and ICT, South Korea; National Institute on Alcohol Abuse and Alcoholism; National Research Foundation; China Scholarship Council; American Heart Association; American Diabetes Association","keywords":"Biology; Thermogenesis; Endocrinology; Internal medicine; Adipose tissue; Methyltransferase; Adipocyte; White adipose tissue; Arginine; Brown adipose tissue; Thermogenin; Mitochondrial biogenesis; Cell biology; Function (biology); Methylation; Genetics; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001709613,0.0003236395,0.0003097181,0.0001890006,0.0002687279,0.0003197232,0.0002673059,0.0003531338,0.001677061],"category_scores_gemma":[0.0002151276,0.0001885904,0.0004208259,0.0002113974,0.0002566286,0.0001749062,0.0003387147,0.0006081849,0.000571289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003998533,"about_ca_system_score_gemma":0.0001622522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007721992,"about_ca_topic_score_gemma":0.001225862,"domain_scores_codex":[0.9997876,0.00002531639,0.000008471885,0.00007184564,0.00004540968,0.00006133994],"domain_scores_gemma":[0.9998801,0.00001095047,0.00004213043,0.00001173083,0.00001542518,0.00003971914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003688981,0.00003581426,0.002712165,0.0001468416,0.00003354224,0.000145957,0.00005579522,0.0001080755,0.9893182,0.0002358202,0.0005793942,0.00625957],"study_design_scores_gemma":[0.0001432224,0.0005238656,0.1128334,0.0000562631,0.0001447149,0.00119198,0.0001603433,0.003031683,0.8468627,0.0006045329,0.03441763,0.00002969911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722592,0.01529812,0.006872483,0.0007379045,0.0003194799,0.00003469269,0.0007480822,0.0003974331,0.003332672],"genre_scores_gemma":[0.9889734,0.00382092,0.001605364,0.0002139236,0.00006060782,0.00002517356,0.001006655,0.00005229406,0.004241685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001677061,"threshold_uncertainty_score":0.005610347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005107435525098753,"score_gpt":0.2184188283077874,"score_spread":0.2133113927826886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}