{"id":"W2975216494","doi":"10.1093/carcin/bgz161","title":"Targeting lysosome function causes selective cytotoxicity in VHL-inactivated renal cell carcinomas","year":2019,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Atlantic Cancer Research Institute; Université de Moncton","funders":"Canadian Institutes of Health Research; New Brunswick Innovation Foundation","keywords":"Lysosome; Biology; Cytotoxic T cell; Cancer research; Autophagy; Cytotoxicity; Cell biology; In vitro; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001552393,0.0001772629,0.0003832553,0.000232802,0.0001407851,0.000260787,0.0001674597,0.0002742305,0.0006423172],"category_scores_gemma":[0.0001878884,0.0001083767,0.0001587447,0.0001539415,0.0001884556,0.0001213604,0.0001767504,0.0003305968,0.0001840499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002191665,"about_ca_system_score_gemma":0.0001939925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005797253,"about_ca_topic_score_gemma":0.0006650375,"domain_scores_codex":[0.9998376,0.00002971601,0.00002168421,0.00002879735,0.00004402086,0.00003812265],"domain_scores_gemma":[0.9998509,0.0000479686,0.00002731563,0.00003039193,0.00001242645,0.00003110643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001683488,0.00005505958,0.0005632296,0.0000179925,0.000006690782,0.0001472931,0.00001993048,0.0001258285,0.9978489,0.00007487924,0.00002050613,0.0009513783],"study_design_scores_gemma":[0.00001809486,0.0006205425,0.006641235,0.000002255522,0.00001782089,0.0006701853,0.00002763999,0.0009415744,0.9904873,0.00003276969,0.0005373055,0.00000334805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987578,0.0003598401,0.0004384355,0.00001821946,0.000004872527,0.000009199008,0.00007969863,0.00002348135,0.0003083637],"genre_scores_gemma":[0.9989424,0.0001730096,0.0002778017,0.00001161028,0.000002451544,0.000009079392,0.0001166126,0.000007582029,0.0004594696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006423172,"threshold_uncertainty_score":0.002148807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01091818277760622,"score_gpt":0.2333581515010879,"score_spread":0.2224399687234816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}