{"id":"W2975219771","doi":"10.1038/s41416-019-0586-3","title":"Systemic MEK inhibition enhances the efficacy of 5-aminolevulinic acid-photodynamic therapy","year":2019,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Memorial University of Newfoundland; Canadian Cancer Society Research Institute; Terry Fox Foundation; Beatrice Hunter Cancer Research Institute; Cancer Research Institute","keywords":"Photodynamic therapy; Medicine; Cancer research; Pharmacology; Dermatology; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001201327,0.0003230189,0.0004352821,0.0001762074,0.00009306478,0.0002778746,0.0001837329,0.0002081121,0.001795575],"category_scores_gemma":[0.00008161772,0.00007623548,0.0001746184,0.00008932471,0.0001705202,0.0001717672,0.0001657348,0.000522599,0.0003193296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003100806,"about_ca_system_score_gemma":0.0002234628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005240179,"about_ca_topic_score_gemma":0.0008879881,"domain_scores_codex":[0.999902,0.00001424778,0.00000670538,0.00002008019,0.00002639685,0.00003068935],"domain_scores_gemma":[0.9999381,0.00001495216,0.00001416356,0.000006515448,0.000007824057,0.000018291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005443884,0.0001648934,0.0001953059,0.0001237092,0.00001465422,0.00003085141,0.00001180668,0.0002276786,0.9917853,0.0001021083,0.0001616289,0.006637757],"study_design_scores_gemma":[0.00004322737,0.001529734,0.002318167,0.000008677127,0.00003918695,0.0001671003,0.000009513887,0.0009943481,0.9925733,0.00002162753,0.002291567,0.000003641177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913535,0.003648578,0.001968425,0.0001131722,0.00004076133,0.00004508255,0.0001407171,0.0001592541,0.002530508],"genre_scores_gemma":[0.9972385,0.0007692095,0.0007071789,0.0000185156,0.000007677939,0.00001710139,0.0001046681,0.00001197398,0.001125083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001795575,"threshold_uncertainty_score":0.006006718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01561563260470442,"score_gpt":0.3275585713042731,"score_spread":0.3119429386995686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}