{"id":"W2975354206","doi":"10.1101/774554","title":"Genome-wide association study of Alzheimer’s disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"FAS Division of Science, Harvard University; Canadian Institutes of Health Research; National Institutes of Health; IXICO; H. Lundbeck A/S; Genentech; Vlaamse regering; Servier; Innovative Medicines Initiative; Vetenskapsrådet; Eisai; ZonMw; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Deutsche Forschungsgemeinschaft; National Research Foundation; European Federation of Pharmaceutical Industries and Associations; Northern California Institute for Research and Education; Alzheimer's Disease Neuroimaging Initiative; Universität zu Lübeck; Pfizer; Biogen; BioClinica; Harvard University; University of Southern California; Västra Götalandsregionen; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; European Commission; Medical Research Council; Meso Scale Diagnostics; Novartis Pharmaceuticals Corporation; Universiteit Antwerpen; Alzheimer's Association","keywords":"Genome-wide association study; Single-nucleotide polymorphism; Biomarker; Genetic association; Frontotemporal dementia; Biology; Genetic architecture; Apolipoprotein E; Biomarker discovery; Disease; Alzheimer's disease; Dementia; Computational biology; Genetics; SNP; Bioinformatics; Phenotype; Genotype; Medicine; Internal medicine; Gene; Proteomics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002917561,0.0005857116,0.001351353,0.001266682,0.0006716506,0.0006971711,0.0009912471,0.000824787,0.002049343],"category_scores_gemma":[0.005555314,0.0001979162,0.0009274561,0.002179523,0.0002319693,0.000249769,0.0009652844,0.0005161584,0.0003113395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003995702,"about_ca_system_score_gemma":0.0005655104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009762906,"about_ca_topic_score_gemma":0.01254469,"domain_scores_codex":[0.9987037,0.0003512293,0.0001432463,0.0004957971,0.0001216539,0.000184348],"domain_scores_gemma":[0.9981463,0.0006196138,0.0003907507,0.000442943,0.0002275431,0.0001728732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004943815,0.0001971967,0.9623773,0.0002630899,0.002879476,0.000866624,0.000119824,0.001561512,0.004376371,0.0003046992,0.01237038,0.009739758],"study_design_scores_gemma":[0.0005274494,0.0001897829,0.9887769,0.00003865899,0.0009564989,0.0007104223,0.00009745116,0.00382791,0.0007461536,0.0002908228,0.003813423,0.00002454691],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9318167,0.0005285447,0.0008855173,0.0002225557,0.00001314374,0.00003532839,0.06604113,0.00005778165,0.0003993291],"genre_scores_gemma":[0.8618532,0.0001573252,0.00217237,0.0001658941,0.00002573039,0.0001474581,0.1351198,0.00001951729,0.0003386906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009762906,"threshold_uncertainty_score":0.01941216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03106637777539855,"score_gpt":0.2918620453086671,"score_spread":0.2607956675332685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}