{"id":"W2975383698","doi":"10.1136/annrheumdis-2019-215386","title":"A head-to-head comparison of the efficacy and safety of ixekizumab and adalimumab in biological-naïve patients with active psoriatic arthritis: 24-week results of a randomised, open-label, blinded-assessor trial","year":2019,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":288,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"Pfizer; Eli Lilly and Company; Amgen","keywords":"Medicine; Ixekizumab; Adalimumab; Psoriatic arthritis; Internal medicine; Adverse effect; Rheumatology; Psoriasis; Quality of life (healthcare); Physical therapy; Secukinumab; Disease; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006376935,0.002548864,0.005769309,0.0005676399,0.000655912,0.00168329,0.001453648,0.003323552,0.007970976],"category_scores_gemma":[0.005505973,0.001461762,0.003305283,0.0004502959,0.002588233,0.001946317,0.0007041178,0.00396327,0.001661966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001157963,"about_ca_system_score_gemma":0.001321341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007170844,"about_ca_topic_score_gemma":0.00131671,"domain_scores_codex":[0.9959276,0.002650703,0.0002859728,0.0005733596,0.0002588514,0.0003034629],"domain_scores_gemma":[0.9952662,0.001814766,0.001147011,0.0005349516,0.0002924466,0.0009446189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9916188,0.002993665,0.0002097355,0.0001974323,0.0004855418,0.000008935586,0.0000243224,0.00007577747,0.0008705949,0.00002212471,0.00009622772,0.003396859],"study_design_scores_gemma":[0.8901483,0.1078101,0.0008617477,0.00001531153,0.0004490647,0.00001423318,0.00001195576,0.0001466566,0.0003024288,0.00006810424,0.0001594984,0.00001249178],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898437,0.004278086,0.0005950834,0.0003924735,0.0005710162,0.002350228,0.0005893667,0.00008964692,0.001290327],"genre_scores_gemma":[0.9912727,0.001698966,0.001069958,0.0005586221,0.0009288893,0.002061784,0.000497002,0.00002533703,0.001886732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007970976,"threshold_uncertainty_score":0.03372484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08465387686902026,"score_gpt":0.365823190280827,"score_spread":0.2811693134118067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}