{"id":"W2975492890","doi":"10.1182/blood.v128.22.326.326","title":"Differential Glycosylation Between Recombinant Factor VIII Produced in Baby Hamster Kidney and Chinese Hamster Ovary Cells Confers Differences in Immunogenicity in a Humanized Hemophilia Α Mouse Model","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Queen's University","funders":"","keywords":"Chinese hamster ovary cell; Immunogenicity; Baby hamster kidney cell; Molecular biology; Biotinylation; Recombinant DNA; Glycan; Biology; Antibody; Antigen; Chemistry; Immunology; Biochemistry; Receptor; Glycoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004257957,0.0006300063,0.0003732277,0.0005720235,0.0001616651,0.0005255443,0.00034336,0.0005458687,0.001191205],"category_scores_gemma":[0.0001764195,0.0002675583,0.0004656425,0.0002751308,0.0003931852,0.0003357772,0.0002322517,0.00119013,0.0004622036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004115192,"about_ca_system_score_gemma":0.0001889631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004890052,"about_ca_topic_score_gemma":0.0003299092,"domain_scores_codex":[0.9995308,0.00008221334,0.00006678226,0.0001150019,0.0001112011,0.00009413122],"domain_scores_gemma":[0.9996892,0.00003730019,0.0001062245,0.00006303011,0.0000303279,0.00007406562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004440416,0.0001649957,0.0001826636,0.00002032025,0.000009036997,0.00006139142,0.00001971382,0.00002487468,0.9985399,0.00007095754,0.00002572653,0.0004364731],"study_design_scores_gemma":[0.000064041,0.002383985,0.004262752,0.000009999409,0.00003598145,0.0005949443,0.00003525785,0.0006019174,0.9902864,0.00005717645,0.001659186,0.000008387982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958485,0.0005671612,0.002239618,0.00006895659,0.00003780701,0.00007003408,0.0003960512,0.00008094985,0.0006909371],"genre_scores_gemma":[0.990155,0.0007630148,0.003566837,0.00007900671,0.00001700942,0.0001360462,0.0009473643,0.00003510254,0.004300606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001191205,"threshold_uncertainty_score":0.003984928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03162279466401596,"score_gpt":0.27489038431422,"score_spread":0.2432675896502041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}