{"id":"W2975494298","doi":"10.1111/jnc.14877","title":"Cellulose ether treatment <i>in vivo</i> generates chronic wasting disease prions with reduced protease resistance and delayed disease progression","year":2019,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Science and Engineering Research Council; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; University of Calgary","keywords":"Chronic wasting disease; In vivo; Inoculation; Biology; Protease; In vitro; Genetically modified mouse; Virology; Persistence (discontinuity); Transgene; Microbiology; Disease; Prion protein; Immunology; Internal medicine; Enzyme; Medicine; Biochemistry; Scrapie","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001798537,0.0005191764,0.0003011637,0.0001983089,0.0001002851,0.0002282722,0.0001763275,0.0003557627,0.001076303],"category_scores_gemma":[0.0001474013,0.0001054103,0.0002719997,0.0001142685,0.0001974283,0.0001889455,0.00008952725,0.0005304875,0.000302232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001964853,"about_ca_system_score_gemma":0.0001674133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007213864,"about_ca_topic_score_gemma":0.0007707531,"domain_scores_codex":[0.9998522,0.00002935226,0.00001720226,0.00002796744,0.00003035629,0.00004290208],"domain_scores_gemma":[0.9997814,0.00005017421,0.0000632952,0.00002560178,0.00002883407,0.00005064963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001767452,0.00004361042,0.00005543568,0.00001468811,0.000003767323,0.00002001801,0.000002984814,0.00001593053,0.9993958,0.00001562869,0.00001537011,0.0002399525],"study_design_scores_gemma":[0.0000141043,0.0007936326,0.001156785,0.00000307923,0.00001069102,0.00008495986,0.000005625674,0.0001642712,0.9972624,0.000007094692,0.0004950313,0.000002295708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959525,0.0008427224,0.001638199,0.00004716117,0.00003622378,0.00003490181,0.0003997058,0.0000552743,0.0009932537],"genre_scores_gemma":[0.9932157,0.0006646076,0.002091439,0.00005458714,0.00001643066,0.00003845186,0.001102182,0.00003461904,0.002781947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001076303,"threshold_uncertainty_score":0.003600597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006169384030683308,"score_gpt":0.2434918896126481,"score_spread":0.2373225055819647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}