{"id":"W2975541626","doi":"10.1093/cid/ciz926","title":"Switching to Tenofovir Alafenamide in Elvitegravir-Based Regimens: Pharmacokinetics and Antiviral Activity in Cerebrospinal Fluid","year":2019,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of Mental Health; University at Buffalo; University of California, San Diego; National Institutes of Health; Gilead Sciences","keywords":"Elvitegravir; Cobicistat; Tenofovir alafenamide; Emtricitabine; Medicine; Cerebrospinal fluid; Pharmacokinetics; Regimen; Pharmacology; Dosing; Internal medicine; Gastroenterology; Human immunodeficiency virus (HIV); Viral load; Immunology; Antiretroviral therapy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004914653,0.0002034402,0.0003700907,0.0001300549,0.0002038759,0.0004054159,0.0001997857,0.0002936098,0.0007041721],"category_scores_gemma":[0.001025747,0.0001034013,0.0002000802,0.0001146081,0.0002005725,0.0003520551,0.00009873428,0.0003352741,0.00008521541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004192768,"about_ca_system_score_gemma":0.0002557035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00115823,"about_ca_topic_score_gemma":0.00154722,"domain_scores_codex":[0.9997606,0.00005559996,0.00002170786,0.00005706739,0.00005615554,0.00004892231],"domain_scores_gemma":[0.9997717,0.00006095508,0.00007138908,0.00001537929,0.00003098897,0.00004962063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1200629,0.01581992,0.2296412,0.0003271608,0.0006557534,0.0007827153,0.00136517,0.001734385,0.2335632,0.0001132284,0.0003951803,0.3955392],"study_design_scores_gemma":[0.01079188,0.2501603,0.6560027,0.00010729,0.000710679,0.002755472,0.001003716,0.006397728,0.06841383,0.0003474825,0.003253783,0.00005505373],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9998047,0.00008277714,0.00002672011,0.000005209719,0.000001603801,0.00001094298,0.000007685746,0.000001071534,0.00005933879],"genre_scores_gemma":[0.9997523,0.00005108182,0.00008293731,0.00001592452,0.000003495029,0.00001224111,0.00002711425,5.965427e-7,0.00005434097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00115823,"threshold_uncertainty_score":0.003042042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01915818136845207,"score_gpt":0.3478262251106489,"score_spread":0.3286680437421968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}