{"id":"W2975604509","doi":"10.1101/787200","title":"<i>Listeria</i> phages induce Cas9 degradation to protect lysogenic genomes","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"University of California, San Francisco; Margaret Q. Landenberger Research Foundation; Vallee Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Canadian Institutes of Health Research; Sandler Foundation; National Institutes of Health; National Science Foundation","keywords":"CRISPR; Lytic cycle; Cas9; Listeria; Biology; Lysogenic cycle; Prophage; Bacteriophage; CRISPR interference; Genetics; Listeria monocytogenes; Gene; Bacteria; Virus; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001414022,0.0003566667,0.0002122789,0.0001410792,0.0001092108,0.0003770936,0.0001768691,0.000219744,0.001903343],"category_scores_gemma":[0.0001798845,0.0001236199,0.0003210066,0.00006210052,0.000165082,0.0001227871,0.0002674369,0.0005798943,0.0007816137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003813551,"about_ca_system_score_gemma":0.0001925625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004407172,"about_ca_topic_score_gemma":0.000346934,"domain_scores_codex":[0.9997857,0.0000264473,0.000024483,0.00005030163,0.00005586488,0.00005725899],"domain_scores_gemma":[0.9997695,0.00003174757,0.00007468207,0.00003292597,0.00003682228,0.00005429817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000498546,0.000009927824,0.0002464048,0.00003004449,0.000004671,0.00002272313,0.000004351513,0.00004818476,0.9986696,0.00006829312,0.0001384149,0.0007075436],"study_design_scores_gemma":[0.000005958416,0.0000857609,0.003203539,0.00000515184,0.000005014982,0.0002165572,0.00001048677,0.0007296457,0.9933547,0.00003410399,0.002345032,0.000004129136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804626,0.002175407,0.009994267,0.0002152555,0.0000739612,0.00003998573,0.0006295021,0.0007154544,0.005693654],"genre_scores_gemma":[0.9934657,0.0002595125,0.002233553,0.0001305607,0.000008706366,0.00001971104,0.0007813086,0.000050681,0.003050151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001903343,"threshold_uncertainty_score":0.006367385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01132249358739103,"score_gpt":0.2507193634426579,"score_spread":0.2393968698552668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}