{"id":"W2975604509","doi":"10.1101/787200","title":"<i>Listeria</i> phages induce Cas9 degradation to protect lysogenic genomes","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"University of California, San Francisco; Margaret Q. Landenberger Research Foundation; Vallee Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Canadian Institutes of Health Research; Sandler Foundation; National Institutes of Health; National Science Foundation","keywords":"CRISPR; Lytic cycle; Cas9; Listeria; Biology; Lysogenic cycle; Prophage; Bacteriophage; CRISPR interference; Genetics; Listeria monocytogenes; Gene; Bacteria; Virus; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003415631,0.0005708685,0.0004305043,0.000178336,0.00008985915,0.0001634051,0.0005907572,0.0006148312,0.00002099745],"category_scores_gemma":[0.0001190414,0.0006408948,0.0001816451,0.0002409744,0.00003634299,0.000007509616,0.0007441741,0.0003799787,0.00009836454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009994521,"about_ca_system_score_gemma":0.0003748657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003150576,"about_ca_topic_score_gemma":0.000005937979,"domain_scores_codex":[0.9975429,0.00007842717,0.0004264445,0.0011459,0.0002648486,0.0005414978],"domain_scores_gemma":[0.9977669,0.00001097706,0.000193054,0.001510837,0.0002662338,0.0002520219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003203068,0.00004081825,0.001012533,0.0002546195,0.0001316922,0.000008070748,0.000007241267,0.001396849,0.9965439,0.00001026661,0.0005482819,0.00001366749],"study_design_scores_gemma":[0.0003257229,0.0001274947,0.0114231,0.0001140325,0.00007186454,6.564748e-8,0.000002929213,0.00009561043,0.9568006,2.890392e-7,0.03025496,0.0007832806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751987,0.003681493,0.01793523,0.0001400295,0.001281874,0.0014138,0.00020807,0.0001221373,0.00001866454],"genre_scores_gemma":[0.9927191,0.00034695,0.005298952,0.0002726207,0.0007904822,0.0003440683,0.000004399658,0.00016267,0.00006079303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03974329,"threshold_uncertainty_score":0.9996042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01132249358739103,"score_gpt":0.2507193634426579,"score_spread":0.2393968698552668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}