{"id":"W2975633130","doi":"10.3390/vaccines7040133","title":"Historical H1N1 Influenza Virus Imprinting Increases Vaccine Protection by Influencing the Activity and Sustained Production of Antibodies Elicited at Vaccination in Ferrets","year":2019,"lang":"en","type":"article","venue":"Vaccines","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"National Institute of Allergy and Infectious Diseases; IWK Health Centre; National Institutes of Health; Nova Scotia Health Research Foundation; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"Vaccination; Virus; Imprinting (psychology); Virology; Immune system; Biology; Antibody; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001427834,0.0002536671,0.0002329625,0.000212621,0.0001017945,0.0002756636,0.0001993237,0.0002527093,0.0008331033],"category_scores_gemma":[0.000249644,0.0001125356,0.0001981351,0.00004004486,0.0003003445,0.0003244291,0.0001460914,0.0004400581,0.0001491434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003305146,"about_ca_system_score_gemma":0.0001030942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004100595,"about_ca_topic_score_gemma":0.0007628633,"domain_scores_codex":[0.9998978,0.00001605842,0.000005756522,0.00003365657,0.00001424732,0.00003246174],"domain_scores_gemma":[0.9998555,0.00002601655,0.00005139085,0.00001393458,0.000008707476,0.00004438464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007021326,0.0001531997,0.003701652,0.00002355255,0.00001267099,0.00006309964,0.00006381447,0.0001113799,0.9924945,0.00003446268,0.00003779873,0.002601859],"study_design_scores_gemma":[0.00005993996,0.007659445,0.1370157,0.00002573596,0.000115061,0.0004082291,0.0002722209,0.001670633,0.8504925,0.0001854971,0.002075124,0.00001993746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993741,0.0001806625,0.0001680836,0.00002702614,0.000008903015,0.000006410981,0.0000295769,0.00001212501,0.0001931222],"genre_scores_gemma":[0.998785,0.0001377877,0.0002802235,0.00003449141,0.000008842512,0.00001488604,0.00006458518,0.000008789578,0.0006654763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008331033,"threshold_uncertainty_score":0.002786994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03438520655806725,"score_gpt":0.3237057605274537,"score_spread":0.2893205539693864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}