{"id":"W2975967351","doi":"10.1002/cbic.201900575","title":"Highly Sensitive RNA‐Cleaving DNAzyme Sensors from Surface‐to‐Surface Product Enrichment","year":2019,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Deoxyribozyme; Cleavage (geology); Biosensor; RNA; Oligonucleotide; Nanotechnology; Chemistry; DNA; Combinatorial chemistry; Materials science; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005820844,0.0006710073,0.0005474542,0.000285393,0.0001118015,0.000653278,0.0009038416,0.0008092364,0.0006706515],"category_scores_gemma":[0.0006295894,0.0004067537,0.000302005,0.0002361183,0.0003298158,0.0005481845,0.0005242467,0.001153875,0.0008864744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003741735,"about_ca_system_score_gemma":0.0002163212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001245697,"about_ca_topic_score_gemma":0.0003201664,"domain_scores_codex":[0.9992688,0.0001222887,0.00004572809,0.000143102,0.0003615491,0.00005853839],"domain_scores_gemma":[0.9997587,0.00007869737,0.00005637571,0.00002167328,0.00005996844,0.0000247003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009421015,0.000008494602,0.00003191763,0.00005397297,0.000003589518,0.00001566287,0.000005755141,0.0001187043,0.9965891,0.0001831101,0.00004605261,0.002934306],"study_design_scores_gemma":[0.000002323101,0.00003348548,0.0001016245,0.000002717162,0.000003054008,0.00004337697,0.000003166189,0.0007914691,0.9977509,0.00005626802,0.001207463,0.000003963859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.38451,0.01285805,0.5908759,0.0007540214,0.0004333075,0.0004437396,0.0005574395,0.002024901,0.007542595],"genre_scores_gemma":[0.6330233,0.006278407,0.3499377,0.0005939791,0.000112694,0.0004055366,0.0008510328,0.0001405203,0.008656817],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0009038416,"threshold_uncertainty_score":0.003078401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006646180193110285,"score_gpt":0.2429883782441489,"score_spread":0.2363421980510386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}