{"id":"W2975972081","doi":"10.1055/a-0979-2322","title":"From the Origins of Pharmacogenetics to First Applications in Psychiatry","year":2019,"lang":"en","type":"review","venue":"Pharmacopsychiatry","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Pharmacogenetics; Relevance (law); Clinical pharmacology; Pharmacogenomics; Psychology; Psychiatry; Medicine; Pharmacology; Biology; Genetics; Political science; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","insufficient_payload"],"category_scores_codex":[0.001096334,0.001323927,0.002792799,0.0006011527,0.0003172298,0.00005070007,0.00312916,0.0008848052,0.00235822],"category_scores_gemma":[0.00003790955,0.001020866,0.00119161,0.002302994,0.0002385048,0.00009695683,0.0006024951,0.002944263,0.001485405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003174926,"about_ca_system_score_gemma":0.001424967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002137749,"about_ca_topic_score_gemma":0.00008583344,"domain_scores_codex":[0.9933978,0.001110606,0.002362622,0.001382367,0.0005746027,0.001172059],"domain_scores_gemma":[0.9951678,0.001589249,0.001110941,0.001306431,0.0001557901,0.0006697826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002146212,0.002905637,0.004149957,0.01313478,0.002535481,0.00001043003,0.00111787,0.001057346,0.0001408799,0.00249306,0.08009214,0.8921478],"study_design_scores_gemma":[0.001865315,0.00004104877,0.00007765342,0.001376618,0.004649899,0.000009985768,0.00009459679,0.0001092458,0.0001202659,0.0003232734,0.9903221,0.001009983],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001114274,0.9681315,0.00009786933,0.0009336171,0.01807433,0.005551131,0.004301662,0.0001002149,0.001695399],"genre_scores_gemma":[0.00050864,0.988489,0.0008939276,0.003032495,0.004641801,0.001494746,0.000467713,0.0002560932,0.0002155294],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.91023,"threshold_uncertainty_score":0.9999512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.177517232113952,"score_gpt":0.5055671253013257,"score_spread":0.3280498931873738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}