{"id":"W2975995592","doi":"10.1038/s41467-019-12187-5","title":"Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":373,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; University of Alberta; University of Ottawa; McGill University; Children's Hospital of Eastern Ontario; Hospital for Sick Children; University of British Columbia; Dalhousie University; BC Children's Hospital; University of Toronto; SickKids Foundation","funders":"Hospital for Sick Children; Government of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Genome Canada; Ontario Genomics; Nationwide Children's Hospital; Pediatric Low Grade Astrocytoma Foundation","keywords":"Receptor tyrosine kinase; Glioma; Cohort; ROS1; Medicine; Oncology; Internal medicine; Biology; Cancer research; Receptor; Cancer; Adenocarcinoma","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001566314,0.0003737347,0.0002541843,0.0008271328,0.0002410082,0.0003380589,0.0001823139,0.0002698507,0.0009490878],"category_scores_gemma":[0.0005399007,0.0001110733,0.0002003406,0.0004462062,0.0002447825,0.000154153,0.0003483569,0.0002126017,0.0002732995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001256218,"about_ca_system_score_gemma":0.0001660736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001040922,"about_ca_topic_score_gemma":0.001731159,"domain_scores_codex":[0.9998455,0.00002194794,0.00001487748,0.00004056355,0.00004035235,0.00003662069],"domain_scores_gemma":[0.9996862,0.00003867292,0.000169772,0.00003112582,0.00002538008,0.00004882099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005454306,0.00004508682,0.8495549,0.00006320867,0.0001010995,0.01028835,0.0005094427,0.0003175624,0.1154798,0.0003726539,0.0003453185,0.0223771],"study_design_scores_gemma":[0.00000636358,0.0001637089,0.9645404,0.0000127819,0.00005314661,0.02453427,0.0003077194,0.0002672098,0.008279554,0.0001978182,0.001625609,0.00001134693],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987769,0.0001725381,0.0002716332,0.00002119016,0.000001676301,0.000006795503,0.0001457655,0.00001367198,0.0005898071],"genre_scores_gemma":[0.9989488,0.0001926587,0.0003081736,0.00001529053,0.000004048543,0.00000562082,0.0003194661,0.00001089873,0.0001950227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001040922,"threshold_uncertainty_score":0.00317502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01069090692963559,"score_gpt":0.2976667161481686,"score_spread":0.2869758092185331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}