{"id":"W2975999253","doi":"10.1007/s11239-019-01962-2","title":"Drug interactions and pharmacogenetic factors contribute to variation in apixaban concentration in atrial fibrillation patients in routine care","year":2019,"lang":"en","type":"article","venue":"Journal of Thrombosis and Thrombolysis","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"London Health Sciences Centre; Western University","funders":"Canadian Institutes of Health Research; Ontario Ministry of Research, Innovation and Science","keywords":"Apixaban; Medicine; Pharmacology; Abcg2; Pharmacogenetics; CYP2C9; Internal medicine; Atrial fibrillation; Warfarin; Rivaroxaban; Cytochrome P450; ATP-binding cassette transporter; Genotype; Transporter; Biology; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002364614,0.0001284273,0.000519613,0.0003259535,0.00002624015,0.00002561169,0.00003445319,0.00004955861,0.00005394098],"category_scores_gemma":[0.00003298549,0.000105879,0.00009577474,0.0003327884,0.00001274891,0.0002369918,0.00001200304,0.0001664649,0.000001105326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001913221,"about_ca_system_score_gemma":0.00004670509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000218065,"about_ca_topic_score_gemma":0.0008363765,"domain_scores_codex":[0.9987661,0.00006400734,0.0006068718,0.0001703499,0.0002364934,0.0001561958],"domain_scores_gemma":[0.9994063,0.00006116275,0.0002340031,0.00006984948,0.0001350729,0.00009362242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002011454,0.00005728364,0.9760688,0.0000525222,0.00006410045,0.000002128765,0.005322033,0.0005607993,0.01696549,0.00001739669,0.000006053257,0.0006822488],"study_design_scores_gemma":[0.004966781,0.000170809,0.9902488,0.0003539504,0.0001593691,0.000001507769,0.001257731,0.0004195971,0.002212083,0.00003715373,0.00006998457,0.0001022237],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982371,0.0004166587,0.00005198689,0.0004188757,0.0003910225,0.0004310052,0.00001393601,0.000003396804,0.00003603679],"genre_scores_gemma":[0.9987732,0.0008892334,0.000161175,0.00004125147,0.00008812752,0.000001039023,0.00002834486,0.00001014039,0.00000755582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01475341,"threshold_uncertainty_score":0.4317621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01145447436116426,"score_gpt":0.2820588769541185,"score_spread":0.2706044025929543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}