{"id":"W2976071796","doi":"10.1158/1538-7445.am2018-1646","title":"Abstract 1646: Discovery and characterization of BAY-6035, a novel benzodiazepine-based SMYD3 inhibitor","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium","funders":"","keywords":"Kinase; Methyltransferase; Drug discovery; Protein kinase domain; Chemistry; Cancer research; Biology; Cell biology; Methylation; Biochemistry; Gene; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000124959,0.0003259603,0.000345975,0.0002415161,0.0001028238,0.0001767359,0.0002866936,0.0001943334,0.001084544],"category_scores_gemma":[0.00009862663,0.00008190144,0.0002052696,0.0002428387,0.0001076665,0.0001515379,0.0001883496,0.0003580115,0.0004690755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002449046,"about_ca_system_score_gemma":0.0002353157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009045527,"about_ca_topic_score_gemma":0.001518049,"domain_scores_codex":[0.9999515,0.000006663497,0.000005097356,0.000008705671,0.00001720745,0.00001087236],"domain_scores_gemma":[0.9999608,0.000003106062,0.000008719728,0.000002720965,0.00001049184,0.0000142316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002614803,0.0001498708,0.0004247762,0.0001547625,0.00002089517,0.0001166908,0.00002354861,0.0006539309,0.9887605,0.00009725791,0.000298019,0.009038329],"study_design_scores_gemma":[0.0004231037,0.004150466,0.005822047,0.00002553663,0.0001091214,0.0009785492,0.0000327558,0.003710957,0.9697955,0.0001245315,0.01480137,0.00002599492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789523,0.008916819,0.006163337,0.0003042041,0.00004313854,0.0002461653,0.001601869,0.0001722084,0.003599812],"genre_scores_gemma":[0.9843667,0.004208859,0.005562528,0.0001487003,0.00001578207,0.00006658176,0.002224826,0.00001762921,0.003388325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001084544,"threshold_uncertainty_score":0.003628135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04798337157261758,"score_gpt":0.3655660300952497,"score_spread":0.3175826585226321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}