{"id":"W2976082919","doi":"10.1093/ije/dyz190","title":"Appraising the causal relevance of DNA methylation for risk of lung cancer","year":2019,"lang":"en","type":"review","venue":"International Journal of Epidemiology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"Medical Research Council; Biotechnology and Biological Sciences Research Council; University of Bristol; Research Councils UK; National Cancer Institute; Cancer Research UK; Wellcome Trust; World Health Organization","keywords":"Lung cancer; DNA methylation; Relevance (law); Methylation; Medicine; Oncology; Bioinformatics; Biology; Computational biology; DNA; Genetics; Gene; Gene expression; Political science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.08066184,0.001700642,0.002839449,0.003742689,0.0006073455,0.002154124,0.002417237,0.002651413,0.003427826],"category_scores_gemma":[0.137827,0.0008621727,0.01302041,0.002973744,0.001784,0.001342249,0.001615647,0.002541731,0.0001930484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001129886,"about_ca_system_score_gemma":0.001852872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00270353,"about_ca_topic_score_gemma":0.001992273,"domain_scores_codex":[0.9459464,0.0446842,0.00280379,0.003430371,0.00247481,0.000660386],"domain_scores_gemma":[0.6934392,0.2858967,0.009208439,0.008074771,0.002713916,0.0006669451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01107931,0.0001409569,0.5014889,0.01356071,0.4195115,0.0005316568,0.0005275622,0.006642308,0.002957347,0.00325427,0.0007956567,0.03950976],"study_design_scores_gemma":[0.003745045,0.00433366,0.2900027,0.003429446,0.646449,0.0008479622,0.0005153362,0.01444844,0.004500301,0.02640102,0.005200844,0.0001262776],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.5863371,0.3424378,0.05520757,0.008376176,0.0008787547,0.0007913799,0.001928693,0.0002543992,0.003788179],"genre_scores_gemma":[0.9856812,0.007715736,0.005062082,0.000705197,0.0002663075,0.0001738042,0.0002430045,0.00002473224,0.0001279782],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.08066184,"threshold_uncertainty_score":0.4265857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09170840663892561,"score_gpt":0.4566447993926461,"score_spread":0.3649363927537205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}