{"id":"W2976164311","doi":"10.1177/2472555219875934","title":"Screening of Chemical Libraries Using a Yeast Model of Retinal Disease","year":2019,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Hospital for Sick Children","keywords":"Rhodopsin; Biology; Retinitis pigmentosa; Yeast; G protein-coupled receptor; Cell biology; Arrestin; Retinal; Genetics; Biochemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003082584,0.0009408686,0.0006666207,0.0008716534,0.0003972661,0.0006625917,0.0004920294,0.0004738988,0.002290495],"category_scores_gemma":[0.0003949429,0.000307839,0.0006539274,0.001232725,0.0002731281,0.0002265022,0.0004339427,0.000642481,0.0009446038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005600434,"about_ca_system_score_gemma":0.0005083454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001887955,"about_ca_topic_score_gemma":0.003368085,"domain_scores_codex":[0.9996843,0.00004680187,0.00002829344,0.00004789945,0.0001412965,0.00005139439],"domain_scores_gemma":[0.9997788,0.00007181123,0.00003556311,0.00002741518,0.0000472035,0.00003927156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002383304,0.0001078368,0.0001876819,0.00008457162,0.00002477433,0.0001723648,0.00001790949,0.001170782,0.9936742,0.0002440004,0.0001318761,0.003945725],"study_design_scores_gemma":[0.00004269239,0.0004611222,0.0005450183,0.000007580394,0.00005105231,0.0001792253,0.00003717668,0.001489248,0.9930702,0.0000764297,0.004029768,0.00001042059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9327424,0.00230247,0.04718178,0.0006109502,0.0001090661,0.0006497202,0.007503505,0.001439422,0.00746069],"genre_scores_gemma":[0.9243016,0.003795748,0.04688494,0.0002132168,0.00002057168,0.0003262593,0.01180596,0.000258498,0.01239317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002290495,"threshold_uncertainty_score":0.007662416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01631999021428888,"score_gpt":0.2293098379326332,"score_spread":0.2129898477183443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}