{"id":"W2976193108","doi":"10.1101/783795","title":"ATF4 regulates neuronal death in models of Parkinson’s Disease","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"","keywords":"ATF4; Substantia nigra; Dopaminergic; Mediator; Cell biology; Programmed cell death; Integrated stress response; Unfolded protein response; Neurotoxin; Transcription factor; Regulator; Neuroprotection; Downregulation and upregulation; Apoptosis; Biology; Puma; Parkinson's disease; Neuroscience; Chemistry; Cancer research; Dopamine; Endocrinology; Internal medicine; Medicine; Biochemistry; Disease; Endoplasmic reticulum; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001768175,0.0004804197,0.0004536294,0.0005030233,0.0002469987,0.0002314294,0.0003249603,0.0004371056,0.001191509],"category_scores_gemma":[0.0001015287,0.0001380516,0.0003433938,0.0002542994,0.0003082035,0.0002855612,0.0002063693,0.0006521303,0.0002908039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004873265,"about_ca_system_score_gemma":0.0001822381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005901977,"about_ca_topic_score_gemma":0.0007286887,"domain_scores_codex":[0.999861,0.00002494996,0.00001524021,0.00002532185,0.00003703184,0.00003640369],"domain_scores_gemma":[0.9999243,0.000006001427,0.00002515076,0.000006631783,0.00001432077,0.00002354753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009803155,0.000169038,0.0003241881,0.0001005769,0.00001469933,0.0001004518,0.00001892212,0.0001082488,0.9958816,0.00008262763,0.0001289683,0.00209048],"study_design_scores_gemma":[0.00009916604,0.001885888,0.008614914,0.00002452627,0.00005660818,0.0004637096,0.00007133438,0.001537292,0.9837249,0.0002258541,0.003286383,0.000009309202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913258,0.003722938,0.0022529,0.0002437483,0.0001090442,0.00005767002,0.0008676348,0.0001669831,0.0012532],"genre_scores_gemma":[0.9923823,0.002056652,0.001946174,0.00008308706,0.00001949745,0.0001048842,0.001074797,0.00002386014,0.002308731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001191509,"threshold_uncertainty_score":0.003985941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01436424391547996,"score_gpt":0.2214247375774944,"score_spread":0.2070604936620144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}