{"id":"W2976351371","doi":"10.1002/bies.201900112","title":"Deubiquitinating Enzymes in Model Systems and Therapy: Redundancy and Compensation Have Implications","year":2019,"lang":"en","type":"review","venue":"BioEssays","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Deubiquitinating enzyme; Biology; Genetics; Gene; Computational biology; Genome; Pseudogene; Phenotype; Functional divergence; Zebrafish; Ubiquitin; Gene family","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002969984,0.0002809149,0.0005735976,0.00009728946,0.00007795572,0.00007590507,0.0001398845,0.0003748592,0.000001916487],"category_scores_gemma":[0.00003803033,0.0002441844,0.00007882803,0.00006369011,0.00006564715,0.000005220916,0.0001271576,0.0001531216,0.000003372924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001978342,"about_ca_system_score_gemma":0.0001685294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002623546,"about_ca_topic_score_gemma":0.000007853491,"domain_scores_codex":[0.9987003,0.0001454467,0.0003728275,0.0004959095,0.00007379118,0.000211759],"domain_scores_gemma":[0.9992741,0.00004062457,0.0002387525,0.0003379589,0.00004892067,0.00005968083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001219193,0.00004658818,0.0002470071,0.009889935,0.00009967741,0.000001534941,0.0001346708,0.00001788385,0.002416451,0.0121279,0.0002459149,0.9747602],"study_design_scores_gemma":[0.0008389981,0.0002379586,0.00006391809,0.005631055,0.0001469758,0.0001372267,0.0001130819,0.0015297,0.001241355,0.0004108354,0.9886079,0.001040948],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000593035,0.9959654,0.0002378992,0.0000231008,0.00005691094,0.001058786,0.0001516488,0.00001311636,0.0019001],"genre_scores_gemma":[0.01178469,0.9867694,0.000298172,0.00002719898,0.000119659,0.0002639801,0.000408874,0.00004492571,0.0002830413],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.988362,"threshold_uncertainty_score":0.9957552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0982883058908947,"score_gpt":0.3409870696483532,"score_spread":0.2426987637574585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}