{"id":"W2976436408","doi":"10.1101/391870","title":"A Chemical Toolbox for the Study of Bromodomains and Epigenetic Signaling","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; University of Toronto; Ottawa Hospital; University Health Network","funders":"Ministero dello Sviluppo Economico; Fundação de Amparo à Pesquisa do Estado de São Paulo; Deutsche Forschungsgemeinschaft; Ontario Ministry of Economic Development and Innovation; Novartis Pharma; Wellcome Trust; Medical Research Council; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Genome Canada; Pfizer","keywords":"Bromodomain; Epigenetics; Acetylation; Computational biology; Histone; Biology; Triple-negative breast cancer; Small molecule; Chemistry; Cell biology; Cancer research; Bioinformatics; Cancer; Biochemistry; Genetics; Breast cancer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006577386,0.0006816345,0.0004380988,0.0009968479,0.0002837321,0.0005254566,0.0005584839,0.0006526081,0.009600411],"category_scores_gemma":[0.0003306359,0.0004289931,0.000472225,0.0004458791,0.0004998833,0.0007190555,0.0007702124,0.001751107,0.003820727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003492399,"about_ca_system_score_gemma":0.0004389188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001943095,"about_ca_topic_score_gemma":0.0003446406,"domain_scores_codex":[0.9998264,0.00003676573,0.00001081417,0.00002914765,0.00007880274,0.00001807749],"domain_scores_gemma":[0.9997999,0.00007568001,0.00002280328,0.00004602534,0.00002038099,0.00003522698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001388604,0.00007698891,0.0001906292,0.0004992722,0.00003887068,0.0002169973,0.00004344787,0.001341434,0.9208333,0.02236813,0.005599466,0.04865266],"study_design_scores_gemma":[0.0001897645,0.0004456913,0.0009302328,0.00009189924,0.00004604944,0.0008956735,0.00002621025,0.005189629,0.6422881,0.01628479,0.3335647,0.00004730929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.08470871,0.04386815,0.7919559,0.005157563,0.00143102,0.0006401104,0.008957337,0.008870338,0.05441082],"genre_scores_gemma":[0.300758,0.04264477,0.603753,0.002033649,0.0006767599,0.001979234,0.006598058,0.001060626,0.04049584],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.009600411,"threshold_uncertainty_score":0.03211653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01468043402017135,"score_gpt":0.2342059691867143,"score_spread":0.2195255351665429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}