{"id":"W2976451193","doi":"10.1016/j.amjcard.2019.09.011","title":"Meta-analysis of Randomized Controlled Trials Assessing the Impact of Proprotein Convertase Subtilisin/Kexin Type 9 Antibodies on Mortality and Cardiovascular Outcomes","year":2019,"lang":"en","type":"review","venue":"The American Journal of Cardiology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Heart Institute; Montreal Neurological Institute and Hospital; Université de Montréal; McGill University Health Centre","funders":"Servier; Sanofi; AstraZeneca; Amgen","keywords":"PCSK9; Medicine; Ezetimibe; Internal medicine; Myocardial infarction; Stroke (engine); Randomized controlled trial; Alirocumab; Coronary artery disease; Odds ratio; Kexin; Placebo; Statin; Confidence interval; Cardiology; Cholesterol; Lipoprotein; LDL receptor; Apolipoprotein A1; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaepi_broad"],"consensus_categories":[],"category_scores_codex":[0.01045006,0.003750552,0.02396123,0.003161658,0.000546922,0.002703407,0.002146245,0.00232242,0.004928818],"category_scores_gemma":[0.02608651,0.001526126,0.03923466,0.003946661,0.0006731417,0.001558182,0.001531577,0.00342158,0.0003867766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001839737,"about_ca_system_score_gemma":0.001921788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004665256,"about_ca_topic_score_gemma":0.008084506,"domain_scores_codex":[0.9917652,0.004256383,0.002180042,0.0008617779,0.000632356,0.0003042306],"domain_scores_gemma":[0.9864016,0.01081715,0.001615029,0.0004620636,0.0005144566,0.0001896767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.008968499,0.00003437657,0.001383509,0.102327,0.8786599,0.00006954537,0.00002414759,0.0004675284,0.0001954209,0.00008131297,0.0003621851,0.007426585],"study_design_scores_gemma":[0.002448929,0.0002644502,0.001501128,0.003419511,0.9912714,0.00003803555,0.00001534704,0.0001492267,0.00007434729,0.0001741091,0.000628642,0.00001478754],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01054594,0.98649,0.00115918,0.0001878069,0.0003994261,0.0002972825,0.0005649696,0.00005557198,0.0002997887],"genre_scores_gemma":[0.2709485,0.7202661,0.003649968,0.001424324,0.000535559,0.0009154727,0.00133206,0.00007384225,0.0008542345],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9760388,"threshold_uncertainty_score":0.0552659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.233076861852075,"score_gpt":0.4647364984891067,"score_spread":0.2316596366370317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}