{"id":"W2976623184","doi":"10.1194/jlr.p094763","title":"Potent reduction of plasma lipoprotein (a) with an antisense oligonucleotide in human subjects does not affect ex vivo fibrinolysis","year":2019,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Fibrinolysis; Lipoprotein(a); Fibrinogen; Ex vivo; In vivo; Internal medicine; Apolipoprotein B; Lipoprotein; Medicine; Plasminogen activator; Endocrinology; Plasminogen activator inhibitor-1; Placebo; Tissue plasminogen activator; Pharmacology; Cholesterol; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00544358,0.0001742272,0.0008506367,0.001085385,0.00009307094,0.0000398686,0.0002063133,0.0001415754,0.0001155424],"category_scores_gemma":[0.0001622138,0.0001077912,0.0003141988,0.0007560307,0.0001527241,0.0002861626,0.00006785168,0.001051738,0.00001125941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002516097,"about_ca_system_score_gemma":0.000475683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001344456,"about_ca_topic_score_gemma":0.000148832,"domain_scores_codex":[0.9954125,0.000751512,0.0006922869,0.0003120699,0.002293747,0.0005378665],"domain_scores_gemma":[0.9977439,0.00007309904,0.0003233571,0.0006963472,0.0008256959,0.0003375715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004496739,0.0006445498,0.01483107,0.001026917,0.00038797,0.0005210998,0.0006499999,0.0002262984,0.9582475,0.00006504504,0.0001091137,0.01879364],"study_design_scores_gemma":[0.005223795,0.008606195,0.09842315,0.001528792,0.00007913659,0.001684779,0.001504687,0.000125872,0.8821757,0.00002817532,0.0004529852,0.0001666968],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997061,0.0001503011,0.00001037608,0.000718488,0.0001909311,0.0009669969,0.000003496009,0.00001020708,0.0008882406],"genre_scores_gemma":[0.9969724,0.0003116992,0.0008214485,0.00001351318,0.001175868,0.000006835116,0.000002027864,0.00004249857,0.0006536721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08359208,"threshold_uncertainty_score":0.4569335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03356010881467813,"score_gpt":0.3406013332280539,"score_spread":0.3070412244133757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}