{"id":"W2976623184","doi":"10.1194/jlr.p094763","title":"Potent reduction of plasma lipoprotein (a) with an antisense oligonucleotide in human subjects does not affect ex vivo fibrinolysis","year":2019,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Fibrinolysis; Lipoprotein(a); Fibrinogen; Ex vivo; In vivo; Internal medicine; Apolipoprotein B; Lipoprotein; Medicine; Plasminogen activator; Endocrinology; Plasminogen activator inhibitor-1; Placebo; Tissue plasminogen activator; Pharmacology; Cholesterol; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007472481,0.0004083231,0.0009495953,0.0001650547,0.0001676291,0.0003633081,0.0001852733,0.000449678,0.001786693],"category_scores_gemma":[0.0003823748,0.0002234805,0.0002813305,0.0001308518,0.0004795886,0.0001624522,0.0001230872,0.0006579445,0.0003493575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001758894,"about_ca_system_score_gemma":0.0002585583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004362658,"about_ca_topic_score_gemma":0.0005690172,"domain_scores_codex":[0.999738,0.00009481246,0.00003079913,0.00005225974,0.00004203796,0.00004210111],"domain_scores_gemma":[0.9998097,0.00005343353,0.00004530444,0.00002125557,0.00001090038,0.00005949605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1077573,0.006364464,0.00458763,0.0002010744,0.0003121762,0.0002610791,0.000121932,0.0002813998,0.8491859,0.0002151061,0.0004681766,0.03024375],"study_design_scores_gemma":[0.04317044,0.7531115,0.07556289,0.00003685587,0.0007703495,0.001128291,0.0001678286,0.001321144,0.1187323,0.0002861299,0.005665502,0.00004670532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982437,0.0007323046,0.0003648868,0.00005093445,0.00003745209,0.00005981044,0.00005708666,0.00002363791,0.0004302272],"genre_scores_gemma":[0.9978142,0.0005054017,0.0004975752,0.0001306471,0.00006390718,0.00009004403,0.0001902979,0.000006338389,0.0007015981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001786693,"threshold_uncertainty_score":0.005977035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03356010881467813,"score_gpt":0.3406013332280539,"score_spread":0.3070412244133757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}