{"id":"W2976758067","doi":"10.1080/15384101.2019.1667705","title":"Ganoderiol F purified from <i>Ganoderma leucocontextum</i> retards cell cycle progression by inhibiting CDK4/CDK6","year":2019,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Fungal Biology and Applications","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"National Natural Science Foundation of China","keywords":"Biology; Cell cycle; Cyclin-dependent kinase 6; Apoptosis; Ganoderma; Cyclin A; Cyclin-dependent kinase; Fetal bovine serum; Cyclin E; Molecular biology; Cancer cell; Biochemistry; Cyclin; Cell; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001635977,0.0002602006,0.0003883053,0.0000451506,0.0001849864,0.00002981262,0.0001897654,0.0003146432,0.0007837691],"category_scores_gemma":[0.0000242538,0.0002270287,0.0001333699,0.0001605653,0.0001047668,0.0001108113,0.0001031275,0.0004695837,0.002116044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005320552,"about_ca_system_score_gemma":0.00008266824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009611574,"about_ca_topic_score_gemma":0.000005286893,"domain_scores_codex":[0.998292,0.0000691895,0.0003741457,0.0006097946,0.0002169553,0.0004379067],"domain_scores_gemma":[0.9988767,0.0001255481,0.0001767244,0.0005405424,0.00007361503,0.0002068579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001063844,0.0002888744,0.008476505,0.00007780603,0.00001525892,0.00001072942,0.000243163,0.000005046571,0.9754882,0.00001885593,0.01341784,0.001851316],"study_design_scores_gemma":[0.002233515,0.0001687553,0.001703414,0.0001320686,0.00006546015,0.000008445173,0.0002499628,0.0007817857,0.9641372,0.0002732581,0.02995082,0.0002953202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9336945,0.001752922,0.00009989909,0.001280105,0.0001700491,0.0008660949,0.00008302936,0.0001896368,0.06186376],"genre_scores_gemma":[0.9908301,0.0000627585,0.0007801482,0.001717187,0.0001908844,0.00008573743,0.0005975903,0.00005063062,0.005685003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05713556,"threshold_uncertainty_score":0.9986609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00517651312773479,"score_gpt":0.2340775746950811,"score_spread":0.2289010615673464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}