{"id":"W2976858486","doi":"10.1021/acschembio.9b00237","title":"Selection of 2'-Deoxy-2'-Fluoroarabino Nucleic Acid (FANA) Aptamers that Bind HIV-1 Integrase with Picomolar Affinity","year":2019,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Medical Research Council Canada; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"Integrase; Aptamer; Nucleic acid; Human immunodeficiency virus (HIV); Selection (genetic algorithm); Computational biology; Virology; Chemistry; Biology; Biochemistry; Molecular biology; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003313228,0.0004084833,0.0003858228,0.0002904146,0.0001939075,0.0003243675,0.0001883413,0.0002482698,0.0009829313],"category_scores_gemma":[0.0004218193,0.0002276486,0.0001593199,0.0002156023,0.0001519581,0.0001157712,0.0001732434,0.0003116487,0.0003595056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003564304,"about_ca_system_score_gemma":0.0001478306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004542616,"about_ca_topic_score_gemma":0.001057056,"domain_scores_codex":[0.9997243,0.00006620856,0.00001677095,0.00007443631,0.00007129378,0.00004690289],"domain_scores_gemma":[0.999831,0.00005351841,0.0000388442,0.00001558598,0.00002379181,0.0000372177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004347061,0.00002531407,0.0002324679,0.00001428526,0.000002941695,0.00003736577,0.00001435786,0.0004145082,0.9969833,0.0000738922,0.00003284461,0.002125096],"study_design_scores_gemma":[0.00001427021,0.0001701346,0.001491382,0.000003247399,0.000009647498,0.0003308093,0.000008976555,0.003362652,0.9927434,0.0000416459,0.001815797,0.000008024032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.964699,0.0007271377,0.03028909,0.0001000999,0.00003181973,0.0002471214,0.0004108046,0.0003788908,0.003115986],"genre_scores_gemma":[0.9692396,0.0003074024,0.02722672,0.00009048764,0.000007170621,0.0001224482,0.0005109518,0.00007406992,0.002421069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009829313,"threshold_uncertainty_score":0.003288269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01028534210916121,"score_gpt":0.2337664216500106,"score_spread":0.2234810795408494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}