{"id":"W2976929154","doi":"10.1158/1078-0432.ccr-19-1223","title":"Randomized Phase II Trial and Tumor Mutational Spectrum Analysis from Cabozantinib versus Chemotherapy in Metastatic Uveal Melanoma (Alliance A091201)","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Institute of General Medical Sciences; National Cancer Institute","keywords":"Cabozantinib; Chemotherapy; Melanoma; Medicine; Oncology; Randomized controlled trial; Metastatic melanoma; Alliance; Internal medicine; Cancer; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001454644,0.001144635,0.001784527,0.0004153445,0.0003249519,0.0008377698,0.0006044221,0.0009934717,0.005982805],"category_scores_gemma":[0.001303796,0.0004128892,0.001020883,0.0003578791,0.0006375141,0.0005321403,0.0003389699,0.002189816,0.0006893914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008596162,"about_ca_system_score_gemma":0.0009137187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007439482,"about_ca_topic_score_gemma":0.002238277,"domain_scores_codex":[0.9994424,0.0003623721,0.00001982427,0.00007987725,0.0000299746,0.00006556065],"domain_scores_gemma":[0.9992394,0.0001776108,0.0002210761,0.00006444213,0.00003930491,0.0002580686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9658002,0.005278629,0.001212221,0.0002546418,0.0006166976,0.0000480128,0.00004446437,0.000711755,0.005301225,0.0001432878,0.001783489,0.01880539],"study_design_scores_gemma":[0.9134101,0.07910348,0.00430878,0.00002557231,0.0003652574,0.00009222443,0.00002083939,0.0008350007,0.0005188144,0.0002836976,0.001023495,0.00001289857],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911931,0.00232643,0.0004605608,0.0007716419,0.0002796965,0.00169675,0.001337657,0.00009169064,0.001842405],"genre_scores_gemma":[0.9875787,0.001242791,0.001204601,0.000996932,0.0002796262,0.003536353,0.002094775,0.0000293957,0.003036915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005982805,"threshold_uncertainty_score":0.02001452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1738103917181097,"score_gpt":0.5433237727058784,"score_spread":0.3695133809877686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}