{"id":"W2976929154","doi":"10.1158/1078-0432.ccr-19-1223","title":"Randomized Phase II Trial and Tumor Mutational Spectrum Analysis from Cabozantinib versus Chemotherapy in Metastatic Uveal Melanoma (Alliance A091201)","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Institute of General Medical Sciences; National Cancer Institute","keywords":"Cabozantinib; Chemotherapy; Melanoma; Medicine; Oncology; Randomized controlled trial; Metastatic melanoma; Alliance; Internal medicine; Cancer; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003520284,0.0001604243,0.001390634,0.0002270831,0.00009353527,0.00002143196,0.0001284248,0.0001236227,0.003325767],"category_scores_gemma":[0.0008978385,0.0001219596,0.0003529785,0.0006972737,0.0005161915,0.00007194157,0.00006531856,0.0006923933,0.0001010347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001249092,"about_ca_system_score_gemma":0.0006455811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001236995,"about_ca_topic_score_gemma":0.0007721192,"domain_scores_codex":[0.9964889,0.001158313,0.0007440915,0.0006177619,0.0005866987,0.0004042423],"domain_scores_gemma":[0.9945752,0.004602132,0.0001461475,0.0003355271,0.0001191458,0.000221838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9214013,0.001991953,0.06872969,0.0000169143,0.003625419,0.0002925284,0.0001278596,0.000005295967,0.00002283748,0.0001150297,0.0001371914,0.003534044],"study_design_scores_gemma":[0.9535881,0.004057595,0.0382254,0.00003886326,0.0009466245,0.000001510181,0.00006258367,0.001454691,0.0001265299,0.0005592469,0.0008284193,0.0001104506],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916873,0.001487588,0.00001313865,0.003724504,0.0005030498,0.002011634,0.00006950078,0.00001404014,0.0004892322],"genre_scores_gemma":[0.9968225,0.0009762556,0.0004494485,0.0002497529,0.0003419374,0.0002652279,0.0001285366,0.00001855631,0.0007478374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03218685,"threshold_uncertainty_score":0.9975854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1738103917181097,"score_gpt":0.5433237727058784,"score_spread":0.3695133809877686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}