{"id":"W2976952919","doi":"10.1089/hum.2019.096","title":"Breathing New Life into TRAIL for Breast Cancer Therapy: Co-Delivery of pTRAIL and Complementary siRNAs Using Lipopolymers","year":2019,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Small interfering RNA; Gene silencing; Breast cancer; Cancer research; Cancer; Apoptosis; Cancer cell; Chemistry; microRNA; Medicine; Transfection; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000113696,0.0002177227,0.0002615059,0.00006028795,0.000109269,0.00002689613,0.0002052835,0.0001026613,0.0004028951],"category_scores_gemma":[9.729853e-7,0.0002022469,0.0001343917,0.00004116552,0.00008691021,0.00001287215,0.00003705084,0.00005929277,0.000001669376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001657732,"about_ca_system_score_gemma":0.0001512221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002199601,"about_ca_topic_score_gemma":0.0001323159,"domain_scores_codex":[0.9989652,0.00003793327,0.0002702246,0.0003659967,0.0001151565,0.0002454784],"domain_scores_gemma":[0.9993948,0.00001047249,0.0001373445,0.0002732615,0.00007815058,0.0001059389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005750642,0.00005039372,0.00497608,0.00002077967,0.0002904495,5.27955e-7,0.0007274184,0.00004377235,0.9640885,0.000008438528,0.001003866,0.02821471],"study_design_scores_gemma":[0.003115907,0.0009266312,0.006459318,0.00003953175,0.00002361696,0.00001933212,0.0004208366,0.0000873842,0.9853472,0.0001115575,0.003106838,0.0003418472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896848,0.009358704,0.0001422054,0.0001199828,0.0001113293,0.0003882805,0.0001240314,0.000009482894,0.00006116134],"genre_scores_gemma":[0.9938797,0.003558647,0.0004544445,0.001296732,0.0004091125,0.00001383505,0.0001147498,0.00004120138,0.0002315248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02787287,"threshold_uncertainty_score":0.8247389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04352578049443392,"score_gpt":0.3192028946958134,"score_spread":0.2756771142013795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}