{"id":"W2976952919","doi":"10.1089/hum.2019.096","title":"Breathing New Life into TRAIL for Breast Cancer Therapy: Co-Delivery of pTRAIL and Complementary siRNAs Using Lipopolymers","year":2019,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Small interfering RNA; Gene silencing; Breast cancer; Cancer research; Cancer; Apoptosis; Cancer cell; Chemistry; microRNA; Medicine; Transfection; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001749372,0.000367168,0.0002627644,0.0001611695,0.0001233514,0.0003998187,0.0001846134,0.00036034,0.0006415457],"category_scores_gemma":[0.0001655645,0.0001539141,0.0003174132,0.0001483665,0.0002435533,0.0004380228,0.0003340008,0.0004790869,0.0004430898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003395728,"about_ca_system_score_gemma":0.0002687574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002793113,"about_ca_topic_score_gemma":0.0004268405,"domain_scores_codex":[0.999833,0.000026284,0.00001705372,0.00004304141,0.00004676947,0.00003388083],"domain_scores_gemma":[0.9999166,0.00001446339,0.00002901338,0.000009372097,0.00001219106,0.00001845205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006741501,0.00002164052,0.00007141192,0.00006339978,0.000006871826,0.00005714403,0.00002108064,0.000161316,0.9963218,0.000151417,0.0000339797,0.003022511],"study_design_scores_gemma":[0.00001212755,0.0001746125,0.0002088721,0.000004009928,0.0000124272,0.0001154888,0.000008700014,0.001059501,0.9962512,0.00002799193,0.002119403,0.000005661002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9675162,0.004691199,0.02418978,0.0002935097,0.00005760714,0.0001178066,0.00009345418,0.0001984998,0.002842042],"genre_scores_gemma":[0.9818065,0.001718356,0.01226943,0.0001344066,0.00001575283,0.00009132452,0.0001073991,0.00003980328,0.003817094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006415457,"threshold_uncertainty_score":0.002463758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04352578049443392,"score_gpt":0.3192028946958134,"score_spread":0.2756771142013795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}