{"id":"W2977098036","doi":"10.1242/dev.178962","title":"EvoChromo: towards a synthesis of chromatin biology and evolution","year":2019,"lang":"en","type":"review","venue":"Development","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Cancer Institute; National Institute of General Medical Sciences; Novo Nordisk; Universitetet i Bergen; Centre National de la Recherche Scientifique; European Commission; Gatsby Charitable Foundation; Novo Nordisk Fonden; Norges Forskningsråd; Company of Biologists; National Institutes of Health; Institut Curie; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; W. M. Keck Foundation; Agence Nationale de la Recherche; National Center for Complementary and Integrative Health; Medical Research Council; Howard Hughes Medical Institute; Université de Recherche Paris Sciences et Lettres; National Science Foundation","keywords":"Biology; Chromatin; Evolutionary biology; Computational biology; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002071895,0.000292254,0.0008305863,0.00009125425,0.00003648727,0.000009829534,0.0002207869,0.0003992292,0.00001302047],"category_scores_gemma":[0.0000618489,0.0002510071,0.000143532,0.00007174097,0.00006028693,0.00000102144,0.0002783163,0.00007717935,0.00002001129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007717341,"about_ca_system_score_gemma":0.0007643661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008765953,"about_ca_topic_score_gemma":0.000006630249,"domain_scores_codex":[0.9987271,0.00006926899,0.0005230579,0.0004011518,0.00007756818,0.0002018034],"domain_scores_gemma":[0.9992179,0.0000206298,0.0003357771,0.0003265551,0.00004954721,0.00004958115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00000296499,0.00003330674,0.0000300418,0.00799155,0.0002975278,6.483917e-7,0.00002670566,6.36081e-7,0.0008359826,0.0001631533,0.0001156862,0.9905018],"study_design_scores_gemma":[0.0001185239,0.00007841612,0.0002995025,0.00200148,0.0002010847,0.00003903566,0.00001346205,0.00001272323,0.0008477008,0.00002918546,0.9959516,0.000407303],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004652437,0.9937574,0.0003947741,0.000003970446,0.0001477801,0.0003801291,0.00007022679,0.000006300698,0.0005870177],"genre_scores_gemma":[0.003449949,0.98997,0.005786681,0.000007014439,0.00005362465,0.00009310716,0.0004054479,0.00003857509,0.0001955969],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9958359,"threshold_uncertainty_score":0.9999942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01881803424470092,"score_gpt":0.2840992372895456,"score_spread":0.2652812030448447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}