{"id":"W2977161965","doi":"10.1186/s13223-019-0375-9","title":"CSACI position statement: Newer generation H1-antihistamines are safer than first-generation H1-antihistamines and should be the first-line antihistamines for the treatment of allergic rhinitis and urticaria","year":2019,"lang":"en","type":"review","venue":"Allergy Asthma and Clinical Immunology","topic":"Allergic Rhinitis and Sensitization","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Allergy Research Corporation; Western University; Memorial University of Newfoundland; McGill University","funders":"","keywords":"Medicine; First line; Cetirizine; SAFER; Dermatology; Pharmacology; Computer science; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005577822,0.001509433,0.00192147,0.001407857,0.003065684,0.006089814,0.004491125,0.03593329,0.02632034],"category_scores_gemma":[0.0170147,0.0006940769,0.00210054,0.001686503,0.002394097,0.00264516,0.001679702,0.02269062,0.03374243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005637588,"about_ca_system_score_gemma":0.02758762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02175715,"about_ca_topic_score_gemma":0.03011235,"domain_scores_codex":[0.993181,0.0004199996,0.0005227209,0.0006097696,0.004354074,0.0009123866],"domain_scores_gemma":[0.976996,0.002398759,0.001712755,0.0003944887,0.01279641,0.005701514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004436614,0.00002676781,0.0001414957,0.0001410752,0.0000118765,0.00006180754,0.0000164974,0.00002555929,0.0001788445,0.0008241574,0.9846741,0.01385345],"study_design_scores_gemma":[0.00009758167,0.00004818464,0.0008126937,0.000540642,0.00003015136,0.0001348132,0.0000475269,0.00009908064,0.0003071543,0.0008590705,0.9969962,0.00002691908],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.0007422944,0.02672226,0.0006056945,0.5630009,0.3456393,0.0003249642,0.00215382,0.0002785431,0.06053229],"genre_scores_gemma":[0.009259319,0.03688091,0.002679121,0.6730186,0.1684735,0.0003906711,0.002573315,0.0002592757,0.1064653],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.03593329,"threshold_uncertainty_score":0.08805031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1343612910720947,"score_gpt":0.3686547354930242,"score_spread":0.2342934444209295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}