{"id":"W2977198565","doi":"10.1158/1078-0432.ccr-19-1038","title":"Comprehensive Transcriptomic Profiling Identifies Breast Cancer Patients Who May Be Spared Adjuvant Systemic Therapy","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Decipher Biosciences (Canada); Ontario Genomics","funders":"Anna och Edwin Bergers Stiftelse; Fru Berta Kamprads Stiftelse; Medicinska Fakulteten, Lunds Universitet; Gunnar Nilssons Cancerstiftelse; Cancerfonden","keywords":"Medicine; Breast cancer; Oncology; Internal medicine; Adjuvant therapy; Cohort; Radiation therapy; Adjuvant; Subgroup analysis; Endocrine system; Cancer; Meta-analysis; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002776355,0.0001884,0.0005056657,0.000459385,0.0001687411,0.0003505388,0.0001515052,0.0002198488,0.0007471136],"category_scores_gemma":[0.0006156719,0.00006877992,0.0003049434,0.0006189393,0.0001538791,0.000173476,0.000259563,0.0001607514,0.0001678298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001792495,"about_ca_system_score_gemma":0.0001846069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003534782,"about_ca_topic_score_gemma":0.0008470741,"domain_scores_codex":[0.9998208,0.00003311661,0.00001630124,0.00006257224,0.00003403269,0.00003316235],"domain_scores_gemma":[0.9997131,0.00006693148,0.0001375649,0.00002103738,0.00002344545,0.00003787757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003338189,0.0001024771,0.8708126,0.0001099698,0.0001852706,0.0003005376,0.00009828518,0.0008954192,0.09528378,0.0001036683,0.0003725292,0.02839722],"study_design_scores_gemma":[0.00004124346,0.0006500666,0.9896352,0.00001364871,0.0001967141,0.0007605004,0.0001447325,0.001653867,0.005740115,0.0001890823,0.0009650332,0.000009740445],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981397,0.0005864538,0.0004026348,0.00003917413,0.000002933094,0.000007952062,0.0005618777,0.00001062909,0.0002485408],"genre_scores_gemma":[0.997802,0.0001799392,0.0004036814,0.00003863995,0.000008618146,0.00001211332,0.001410738,0.000003514909,0.0001408719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007471136,"threshold_uncertainty_score":0.002499342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1239290929463223,"score_gpt":0.4498854712527536,"score_spread":0.3259563783064313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}