{"id":"W2977222066","doi":"10.3390/proteomes7040034","title":"Unbiased Thiol-Labeling and Top-Down Proteomic Analyses Implicate Multiple Proteins in the Late Steps of Regulated Secretion","year":2019,"lang":"en","type":"article","venue":"Proteomes","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University; University of Northern British Columbia","funders":"NHLBI Division of Intramural Research; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canadian Institutes of Health Research; National Institute of Child Health and Human Development; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Fondation pour la Recherche Médicale","keywords":"Exocytosis; Secretion; Rab; Chemistry; Vesicle; Vesicle fusion; Biochemistry; Secretory pathway; Cell biology; Biology; Membrane; Golgi apparatus; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005163254,0.0007586954,0.0005654673,0.0003731167,0.0003731311,0.0006197693,0.0003591503,0.0003724145,0.0005828678],"category_scores_gemma":[0.0003174476,0.0002955747,0.0004750467,0.0003494947,0.00043815,0.0004385689,0.0003396369,0.0007800652,0.0005012763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004240556,"about_ca_system_score_gemma":0.0004139533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004306345,"about_ca_topic_score_gemma":0.001139551,"domain_scores_codex":[0.9996594,0.00003991008,0.00002602815,0.00008892204,0.0001367342,0.00004910985],"domain_scores_gemma":[0.9998195,0.00004337956,0.00004383565,0.00002506201,0.00004367387,0.00002459865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002687748,0.000006116849,0.00008785264,0.00003219963,0.000006490378,0.00002061047,0.000006460914,0.00001696613,0.99914,0.00005071368,0.00001185288,0.0005939203],"study_design_scores_gemma":[0.000001946838,0.00003599842,0.001622633,0.000002280292,0.00001231317,0.0001016663,0.000008632052,0.0002082438,0.9974238,0.00003137841,0.0005481698,0.00000299906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9070882,0.005529298,0.08243951,0.0004400303,0.00009942822,0.0001700346,0.001385036,0.0004453468,0.0024033],"genre_scores_gemma":[0.9262465,0.006566805,0.06042002,0.0003422115,0.00003641329,0.0001612459,0.002027225,0.0001413907,0.00405815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007586954,"threshold_uncertainty_score":0.003076792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01701062212031666,"score_gpt":0.2574438769059506,"score_spread":0.240433254785634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}