{"id":"W2977222066","doi":"10.3390/proteomes7040034","title":"Unbiased Thiol-Labeling and Top-Down Proteomic Analyses Implicate Multiple Proteins in the Late Steps of Regulated Secretion","year":2019,"lang":"en","type":"article","venue":"Proteomes","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University; University of Northern British Columbia","funders":"NHLBI Division of Intramural Research; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canadian Institutes of Health Research; National Institute of Child Health and Human Development; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Fondation pour la Recherche Médicale","keywords":"Exocytosis; Secretion; Rab; Chemistry; Vesicle; Vesicle fusion; Biochemistry; Secretory pathway; Cell biology; Biology; Membrane; Golgi apparatus; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003528773,0.0001393382,0.0001753362,0.00006383731,0.00004230914,0.00001840207,0.0001422764,0.0001352559,0.00002359145],"category_scores_gemma":[0.00003048302,0.0001016969,0.00006581363,0.0001426587,0.00005231868,0.000007701728,0.00003158662,0.0001101218,0.000004700992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007375705,"about_ca_system_score_gemma":0.00003213959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001783879,"about_ca_topic_score_gemma":0.00007814134,"domain_scores_codex":[0.9990727,0.00009079418,0.0002629086,0.0002652038,0.000128508,0.0001799285],"domain_scores_gemma":[0.9994713,0.0000107752,0.0001248402,0.0003171693,0.00004778114,0.00002812463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001242958,0.00003539118,0.05567049,0.00008668548,0.00002429205,5.584682e-7,0.0002338838,0.0001250824,0.9431645,0.00001644461,0.0000010633,0.0005172825],"study_design_scores_gemma":[0.001043918,0.000265199,0.1132895,0.00006025581,0.00002310571,0.00000303214,0.0001195139,0.001184084,0.8832099,0.0002068043,0.0004232429,0.0001713952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962125,0.0003333557,0.001123518,0.0001460122,0.000019708,0.002050916,0.00001145293,0.00001071892,0.00009177873],"genre_scores_gemma":[0.9985858,0.0001129848,0.0004690086,0.00003051995,0.00002917863,0.000153283,0.0004853335,0.00001479626,0.0001190523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05995462,"threshold_uncertainty_score":0.4147079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01701062212031666,"score_gpt":0.2574438769059506,"score_spread":0.240433254785634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}