{"id":"W2977225483","doi":"10.1016/j.tet.2019.130618","title":"1,2-Anti aldol methodologies used in natural product synthesis","year":2019,"lang":"en","type":"article","venue":"Tetrahedron","topic":"Asymmetric Synthesis and Catalysis","field":"Chemistry","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"University of Alberta","keywords":"Chemistry; Aldol reaction; Natural product; Natural (archaeology); Product (mathematics); Organic chemistry; Combinatorial chemistry; Biochemical engineering; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006326255,0.0002440607,0.000560646,0.0002405258,0.00003708424,0.00004005703,0.0004460033,0.0001331411,0.00153069],"category_scores_gemma":[0.001540325,0.0002052023,0.0001869673,0.0005659158,0.00005180679,0.0001604013,0.0000918941,0.0002876441,0.0004145499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001168113,"about_ca_system_score_gemma":0.00003766237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001801473,"about_ca_topic_score_gemma":0.00002016465,"domain_scores_codex":[0.9982267,0.00008369389,0.0003488188,0.0005725325,0.0003417659,0.0004264702],"domain_scores_gemma":[0.997748,0.001289269,0.0001255476,0.0007557936,0.00003128735,0.00005006434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006509936,0.0001868121,0.3453722,0.0003093973,0.0001998531,0.00002813444,0.0003503519,0.00005975389,0.3136842,0.000171203,0.0006326649,0.3389403],"study_design_scores_gemma":[0.0002772291,0.000009886202,0.05013468,0.0000744593,0.00006673616,0.000009455552,0.0008264985,0.0002000604,0.944928,0.0001076681,0.002968405,0.0003969014],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.968121,0.001409269,0.00001586451,0.0002512729,0.0002055097,0.0001123306,0.000009350567,0.0001675827,0.02970783],"genre_scores_gemma":[0.9950864,0.00005398896,0.001733613,0.00002871362,0.0001112882,0.00003932962,0.00001118067,0.00003521847,0.002900255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6312438,"threshold_uncertainty_score":0.999382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03162108212389458,"score_gpt":0.2791496855278773,"score_spread":0.2475286034039827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}