{"id":"W2977278535","doi":"10.1186/s12936-019-2980-y","title":"Uptake of a fluorescently tagged chloroquine analogue is reduced in CQ-resistant compared to CQ-sensitive Plasmodium falciparum parasites","year":2019,"lang":"en","type":"article","venue":"Malaria Journal","topic":"Malaria Research and Control","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Deutscher Akademischer Austauschdienst","keywords":"Plasmodium falciparum; Chloroquine; Intracellular; Malaria; Verapamil; Biology; Cytosol; IC50; Drug resistance; Vacuole; Parasite hosting; Microbiology; Multiple drug resistance; Pharmacology; In vitro; Chemistry; Biochemistry; Immunology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001151942,0.0003203835,0.001042564,0.000704568,0.00009347087,0.00008840454,0.000311311,0.0001747629,0.001440888],"category_scores_gemma":[0.0004760691,0.0002686126,0.0002779354,0.0006351611,0.0000747193,0.000145227,0.0001076371,0.0009469679,0.000207727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002302189,"about_ca_system_score_gemma":0.0005405575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00021842,"about_ca_topic_score_gemma":0.0001900264,"domain_scores_codex":[0.9964569,0.0002192438,0.0009950063,0.0004378614,0.0009778107,0.0009132219],"domain_scores_gemma":[0.9978138,0.0001370035,0.0002910787,0.0004947687,0.0005322295,0.0007311689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.03255531,0.0008691143,0.04160039,0.0001681477,0.0007063025,0.001280421,0.001779728,0.0001888421,0.9108611,0.001482688,0.007041661,0.001466267],"study_design_scores_gemma":[0.01475069,0.002430076,0.9204141,0.0008052352,0.000161054,0.0004409803,0.001138509,0.004164503,0.05214333,0.0001447074,0.003027225,0.0003795933],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793175,0.0001942853,0.0001456312,0.01685239,0.0003002676,0.001398612,0.0001007184,0.00002218124,0.001668414],"genre_scores_gemma":[0.9966077,0.00003422273,0.001120603,0.0007863726,0.0002513192,0.00002700826,0.00003928533,0.00003915964,0.001094365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8788137,"threshold_uncertainty_score":0.9999766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01882867101465578,"score_gpt":0.286141262938402,"score_spread":0.2673125919237462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}