{"id":"W2977278535","doi":"10.1186/s12936-019-2980-y","title":"Uptake of a fluorescently tagged chloroquine analogue is reduced in CQ-resistant compared to CQ-sensitive Plasmodium falciparum parasites","year":2019,"lang":"en","type":"article","venue":"Malaria Journal","topic":"Malaria Research and Control","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Deutscher Akademischer Austauschdienst","keywords":"Plasmodium falciparum; Chloroquine; Intracellular; Malaria; Verapamil; Biology; Cytosol; IC50; Drug resistance; Vacuole; Parasite hosting; Microbiology; Multiple drug resistance; Pharmacology; In vitro; Chemistry; Biochemistry; Immunology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001248168,0.0002087105,0.0002561654,0.0001557695,0.00008922997,0.0002023525,0.000177969,0.0002826168,0.001887626],"category_scores_gemma":[0.0001876027,0.0001612542,0.0001743911,0.0001742527,0.000151511,0.0001875968,0.0001426217,0.0003900864,0.0004720154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00025417,"about_ca_system_score_gemma":0.00007288172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001307294,"about_ca_topic_score_gemma":0.0009801576,"domain_scores_codex":[0.999838,0.00002704467,0.00001492985,0.00003629796,0.00005442243,0.00002930155],"domain_scores_gemma":[0.9998461,0.00003239425,0.00004020671,0.00001127745,0.00004009857,0.00002998539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009748829,0.00001109557,0.0001615782,0.00002963493,0.000002709824,0.00001968357,0.00001658518,0.00001985635,0.9993533,0.00002019242,0.0000347922,0.0002329534],"study_design_scores_gemma":[0.00001420563,0.0006437287,0.02458323,0.00001213633,0.00001807216,0.0003186353,0.00007297278,0.001519098,0.9714125,0.00002346607,0.001371851,0.00001001882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959992,0.0007032986,0.001192043,0.00005988188,0.0000108567,0.00001217989,0.0007373603,0.00003872782,0.001246624],"genre_scores_gemma":[0.9940512,0.0003944922,0.001398011,0.00004118151,0.000005579405,0.00002294073,0.001568039,0.00002496156,0.002493576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001887626,"threshold_uncertainty_score":0.006314695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01882867101465578,"score_gpt":0.286141262938402,"score_spread":0.2673125919237462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}