{"id":"W2977288321","doi":"10.1172/jci.insight.129110","title":"KIAA0317 regulates pulmonary inflammation through SOCS2 degradation","year":2019,"lang":"en","type":"article","venue":"JCI Insight","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"Inflammation; SOCS2; Proinflammatory cytokine; Cytokine; Immunology; Ubiquitin ligase; Medicine; Mediator; Biology; Ubiquitin; Internal medicine; Suppressor; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001429179,0.0003974146,0.0003043555,0.0003517661,0.0002375689,0.0004625826,0.0002145602,0.0002364738,0.001678767],"category_scores_gemma":[0.0001140852,0.000135323,0.0003787025,0.0002196574,0.0003177095,0.000198177,0.0002388697,0.0005843934,0.0005301536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004456449,"about_ca_system_score_gemma":0.0004654457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008491987,"about_ca_topic_score_gemma":0.001489232,"domain_scores_codex":[0.9998553,0.0000194651,0.00001537025,0.0000219446,0.00003513834,0.00005270092],"domain_scores_gemma":[0.9998672,0.00000858589,0.00005238771,0.00000832023,0.00001570181,0.00004769382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003578017,0.00004096176,0.0007220806,0.00009191645,0.00002054232,0.0001365374,0.00001432182,0.0001552346,0.9946837,0.0001973485,0.0001942732,0.003385286],"study_design_scores_gemma":[0.00007691245,0.000527185,0.01312291,0.00001558183,0.00003709972,0.001041484,0.00006230716,0.001313118,0.9765718,0.0001439282,0.00707268,0.0000149422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769219,0.01400649,0.003574145,0.0004653959,0.0001031573,0.00004259292,0.001016916,0.0003122112,0.003557331],"genre_scores_gemma":[0.9944137,0.002382625,0.00105844,0.00009581147,0.00001434226,0.00002050981,0.0004631901,0.00001510825,0.001536335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001678767,"threshold_uncertainty_score":0.005616009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02267500593321194,"score_gpt":0.2682542265388007,"score_spread":0.2455792206055887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}